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Differential effects of the immunosuppressive calcineurin inhibitors cyclosporine-A and tacrolimus on ovulation in a murine model

STUDY QUESTION: Do therapeutic levels of cyclosporine-A and tacrolimus affect ovulation in a rat gonadotrophin-induced ovulation model? SUMMARY ANSWER: Cyclosporine-A, but not tacrolimus, decreases ovulation rate when administered for 5 days before induced ovulation. WHAT IS KNOWN ALREADY: The mains...

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Detalles Bibliográficos
Autores principales:	Zakerkish, F, Soriano, M J, Novella-Mestre, E, Brännström, M, Díaz-García, C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111498/ https://www.ncbi.nlm.nih.gov/pubmed/33997300 http://dx.doi.org/10.1093/hropen/hoab012

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