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GW117: A novel serotonin (5‐HT(2C)) receptor antagonist and melatonin (MT(1)/MT(2)) receptor agonist with potential antidepressant‐like activity in rodents
AIMS: To evaluate the antidepressant‐like effect of compound GW117 in rodents using in vitro binding and uptake assays as well in vivo behavioral tests. METHODS: We investigated the target profile of GW117 using [(35)S]‐GTPγS and [(3)H]PIP binding. Using the forced swimming test and chronic unpredic...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111499/ https://www.ncbi.nlm.nih.gov/pubmed/33650297 http://dx.doi.org/10.1111/cns.13630 |