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GW117: A novel serotonin (5‐HT(2C)) receptor antagonist and melatonin (MT(1)/MT(2)) receptor agonist with potential antidepressant‐like activity in rodents

AIMS: To evaluate the antidepressant‐like effect of compound GW117 in rodents using in vitro binding and uptake assays as well in vivo behavioral tests. METHODS: We investigated the target profile of GW117 using [(35)S]‐GTPγS and [(3)H]PIP binding. Using the forced swimming test and chronic unpredic...

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Detalles Bibliográficos
Autores principales: Gao, Nana, Zheng, Wei, Murezati, Tiliwaerde, Gu, Wei, Li, Xiaorong, Jin, Zengliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111499/
https://www.ncbi.nlm.nih.gov/pubmed/33650297
http://dx.doi.org/10.1111/cns.13630

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