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Plasma amyloid β levels in Alzheimer’s disease and cognitively normal controls in Syrian population

Background: The pathogenesis of Alzheimer’s disease (AD) is believed to be occurred by the production of neurotic plaques of the beta-amyloid peptide (Aβ) and deposition of them. Therefore, biomarkers of abnormal Aβ processing may represent before the AD clinical biomarkers, which could be benefit f...

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Autores principales: Manafikhi, Rafah, Haik, M. Bassam, Lahdo, Raghda, AlQuobaili, Faizeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iran University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111637/
https://www.ncbi.nlm.nih.gov/pubmed/33996670
http://dx.doi.org/10.47176/mjiri.35.19
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author Manafikhi, Rafah
Haik, M. Bassam
Lahdo, Raghda
AlQuobaili, Faizeh
author_facet Manafikhi, Rafah
Haik, M. Bassam
Lahdo, Raghda
AlQuobaili, Faizeh
author_sort Manafikhi, Rafah
collection PubMed
description Background: The pathogenesis of Alzheimer’s disease (AD) is believed to be occurred by the production of neurotic plaques of the beta-amyloid peptide (Aβ) and deposition of them. Therefore, biomarkers of abnormal Aβ processing may represent before the AD clinical biomarkers, which could be benefit for a successful disease management that may prevent the AD development. The aim of this study is to investigate of plasma Aβ40,42 levels in Alzheimer's patients in Syria and thus determine whether they may have a potential role as biomarker for identifying and predicting AD. Methods: In this cross-sectional study, the plasma levels of Aβ1-40 and Aβ1-42 were investigated in two groups represent Syrian population, AD group; clinically diagnosed AD patients (n=50) and CN group; cognitively normal participants (n=33). This study first determined the reference interval of plasma Aβ1-40 and Aβ1-42 for cognitively normal Syrian. Results were analyzed using SPSS, 24, depending on independent-samples t test, considering that the value of p < 0.05 is statistically significant. Results: The results showed that the plasma levels of Aβ1-40 (p<0.001, OR=1.031, 95%CI: 1.012-1.051) and Aβ1-42 (p<0.001, OR=1.306, 95%CI: 1.145-1.490) were significantly higher in AD patients than in cognitively normal participants, and no significant association was shown between both of education and sex with plasma Aβ levels. Conclusion: The plasma levels of Aβ1-40 and Aβ1-42 could be potential biomarkers for identifying and predicting AD.
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spelling pubmed-81116372021-05-13 Plasma amyloid β levels in Alzheimer’s disease and cognitively normal controls in Syrian population Manafikhi, Rafah Haik, M. Bassam Lahdo, Raghda AlQuobaili, Faizeh Med J Islam Repub Iran Original Article Background: The pathogenesis of Alzheimer’s disease (AD) is believed to be occurred by the production of neurotic plaques of the beta-amyloid peptide (Aβ) and deposition of them. Therefore, biomarkers of abnormal Aβ processing may represent before the AD clinical biomarkers, which could be benefit for a successful disease management that may prevent the AD development. The aim of this study is to investigate of plasma Aβ40,42 levels in Alzheimer's patients in Syria and thus determine whether they may have a potential role as biomarker for identifying and predicting AD. Methods: In this cross-sectional study, the plasma levels of Aβ1-40 and Aβ1-42 were investigated in two groups represent Syrian population, AD group; clinically diagnosed AD patients (n=50) and CN group; cognitively normal participants (n=33). This study first determined the reference interval of plasma Aβ1-40 and Aβ1-42 for cognitively normal Syrian. Results were analyzed using SPSS, 24, depending on independent-samples t test, considering that the value of p < 0.05 is statistically significant. Results: The results showed that the plasma levels of Aβ1-40 (p<0.001, OR=1.031, 95%CI: 1.012-1.051) and Aβ1-42 (p<0.001, OR=1.306, 95%CI: 1.145-1.490) were significantly higher in AD patients than in cognitively normal participants, and no significant association was shown between both of education and sex with plasma Aβ levels. Conclusion: The plasma levels of Aβ1-40 and Aβ1-42 could be potential biomarkers for identifying and predicting AD. Iran University of Medical Sciences 2021-02-08 /pmc/articles/PMC8111637/ /pubmed/33996670 http://dx.doi.org/10.47176/mjiri.35.19 Text en © 2021 Iran University of Medical Sciences https://creativecommons.org/licenses/by-nc-sa/1.0/This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial-ShareAlike 1.0 License (CC BY-NC-SA 1.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Manafikhi, Rafah
Haik, M. Bassam
Lahdo, Raghda
AlQuobaili, Faizeh
Plasma amyloid β levels in Alzheimer’s disease and cognitively normal controls in Syrian population
title Plasma amyloid β levels in Alzheimer’s disease and cognitively normal controls in Syrian population
title_full Plasma amyloid β levels in Alzheimer’s disease and cognitively normal controls in Syrian population
title_fullStr Plasma amyloid β levels in Alzheimer’s disease and cognitively normal controls in Syrian population
title_full_unstemmed Plasma amyloid β levels in Alzheimer’s disease and cognitively normal controls in Syrian population
title_short Plasma amyloid β levels in Alzheimer’s disease and cognitively normal controls in Syrian population
title_sort plasma amyloid β levels in alzheimer’s disease and cognitively normal controls in syrian population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111637/
https://www.ncbi.nlm.nih.gov/pubmed/33996670
http://dx.doi.org/10.47176/mjiri.35.19
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