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Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection
Human papillomavirus (HPV) is a sexually transmitted infection common among men and women of reproductive age worldwide. HPV viruses are associated with epithelial lesions and cancers. HPV infections have been shown to be significantly associated with many adverse effects in reproductive function. I...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111735/ https://www.ncbi.nlm.nih.gov/pubmed/33971936 http://dx.doi.org/10.1186/s13027-021-00368-1 |
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author | Isaguliants, Maria Krasnyak, Stepan Smirnova, Olga Colonna, Vincenza Apolikhin, Oleg Buonaguro, Franco M. |
author_facet | Isaguliants, Maria Krasnyak, Stepan Smirnova, Olga Colonna, Vincenza Apolikhin, Oleg Buonaguro, Franco M. |
author_sort | Isaguliants, Maria |
collection | PubMed |
description | Human papillomavirus (HPV) is a sexually transmitted infection common among men and women of reproductive age worldwide. HPV viruses are associated with epithelial lesions and cancers. HPV infections have been shown to be significantly associated with many adverse effects in reproductive function. Infection with HPVs, specifically of high-oncogenic risk types (HR HPVs), affects different stages of human reproduction, resulting in a series of adverse outcomes: 1) reduction of male fertility (male infertility), characterized by qualitative and quantitative semen alterations; 2) impairment of couple fertility with increase of blastocyst apoptosis and reduction of endometrial implantation of trophoblastic cells; 3) defects of embryos and fetal development, with increase of spontaneous abortion and spontaneous preterm birth. The actual molecular mechanism(s) by which HPV infection is involved remain unclear. HPV-associated infertility as Janus, has two faces: one reflecting anti-HPV immunity, and the other, direct pathogenic effects of HPVs, specifically, of HR HPVs on the infected/HPV-replicating cells. Adverse effects observed for HR HPVs differ depending on the genotype of infecting virus, reflecting differential response of the host immune system as well as functional differences between HPVs and their individual proteins/antigens, including their ability to induce genetic instability/DNA damage. Review summarizes HPV involvement in all reproductive stages, evaluate the adverse role(s) played by HPVs, and identifies mechanisms of viral pathogenicity, common as well as specific for each stage of the reproduction process. |
format | Online Article Text |
id | pubmed-8111735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81117352021-05-11 Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection Isaguliants, Maria Krasnyak, Stepan Smirnova, Olga Colonna, Vincenza Apolikhin, Oleg Buonaguro, Franco M. Infect Agent Cancer Review Human papillomavirus (HPV) is a sexually transmitted infection common among men and women of reproductive age worldwide. HPV viruses are associated with epithelial lesions and cancers. HPV infections have been shown to be significantly associated with many adverse effects in reproductive function. Infection with HPVs, specifically of high-oncogenic risk types (HR HPVs), affects different stages of human reproduction, resulting in a series of adverse outcomes: 1) reduction of male fertility (male infertility), characterized by qualitative and quantitative semen alterations; 2) impairment of couple fertility with increase of blastocyst apoptosis and reduction of endometrial implantation of trophoblastic cells; 3) defects of embryos and fetal development, with increase of spontaneous abortion and spontaneous preterm birth. The actual molecular mechanism(s) by which HPV infection is involved remain unclear. HPV-associated infertility as Janus, has two faces: one reflecting anti-HPV immunity, and the other, direct pathogenic effects of HPVs, specifically, of HR HPVs on the infected/HPV-replicating cells. Adverse effects observed for HR HPVs differ depending on the genotype of infecting virus, reflecting differential response of the host immune system as well as functional differences between HPVs and their individual proteins/antigens, including their ability to induce genetic instability/DNA damage. Review summarizes HPV involvement in all reproductive stages, evaluate the adverse role(s) played by HPVs, and identifies mechanisms of viral pathogenicity, common as well as specific for each stage of the reproduction process. BioMed Central 2021-05-10 /pmc/articles/PMC8111735/ /pubmed/33971936 http://dx.doi.org/10.1186/s13027-021-00368-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Isaguliants, Maria Krasnyak, Stepan Smirnova, Olga Colonna, Vincenza Apolikhin, Oleg Buonaguro, Franco M. Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection |
title | Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection |
title_full | Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection |
title_fullStr | Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection |
title_full_unstemmed | Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection |
title_short | Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection |
title_sort | genetic instability and anti-hpv immune response as drivers of infertility associated with hpv infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111735/ https://www.ncbi.nlm.nih.gov/pubmed/33971936 http://dx.doi.org/10.1186/s13027-021-00368-1 |
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