Biogenesis, cellular effects, and biomarker value of circHIPK3

Competing endogenous RNAs (ceRNAs) can indirectly regulate gene expression by competitively binding to microRNA(miRNA) through miRNA response elements (MREs) to affect miRNA-induced gene regulation, which is of great biological significance. Among them, circular RNA (circRNA) has become a hotspot du...

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Detalles Bibliográficos
Autores principales: Fu, Yihan, Sun, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111742/
https://www.ncbi.nlm.nih.gov/pubmed/33975598
http://dx.doi.org/10.1186/s12935-021-01956-2
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author Fu, Yihan
Sun, Hong
author_facet Fu, Yihan
Sun, Hong
author_sort Fu, Yihan
collection PubMed
description Competing endogenous RNAs (ceRNAs) can indirectly regulate gene expression by competitively binding to microRNA(miRNA) through miRNA response elements (MREs) to affect miRNA-induced gene regulation, which is of great biological significance. Among them, circular RNA (circRNA) has become a hotspot due to its highest binding capacity. A specific circRNA discussed in this review, circHIPK3, has been studied for its biological characteristics, function, cellular effects and its relationship with tumors and various diseases. Here, we review the recent researches about circHIPK3 in detail and aim to elucidate accurate conclusions from them. These circHIPK3-miRNAs-mRNA pathways will further advance the application of circHIPK3 in diseases development, early diagnosis and gene targeting therapy.
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spelling pubmed-81117422021-05-11 Biogenesis, cellular effects, and biomarker value of circHIPK3 Fu, Yihan Sun, Hong Cancer Cell Int Review Competing endogenous RNAs (ceRNAs) can indirectly regulate gene expression by competitively binding to microRNA(miRNA) through miRNA response elements (MREs) to affect miRNA-induced gene regulation, which is of great biological significance. Among them, circular RNA (circRNA) has become a hotspot due to its highest binding capacity. A specific circRNA discussed in this review, circHIPK3, has been studied for its biological characteristics, function, cellular effects and its relationship with tumors and various diseases. Here, we review the recent researches about circHIPK3 in detail and aim to elucidate accurate conclusions from them. These circHIPK3-miRNAs-mRNA pathways will further advance the application of circHIPK3 in diseases development, early diagnosis and gene targeting therapy. BioMed Central 2021-05-11 /pmc/articles/PMC8111742/ /pubmed/33975598 http://dx.doi.org/10.1186/s12935-021-01956-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Fu, Yihan
Sun, Hong
Biogenesis, cellular effects, and biomarker value of circHIPK3
title Biogenesis, cellular effects, and biomarker value of circHIPK3
title_full Biogenesis, cellular effects, and biomarker value of circHIPK3
title_fullStr Biogenesis, cellular effects, and biomarker value of circHIPK3
title_full_unstemmed Biogenesis, cellular effects, and biomarker value of circHIPK3
title_short Biogenesis, cellular effects, and biomarker value of circHIPK3
title_sort biogenesis, cellular effects, and biomarker value of circhipk3
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111742/
https://www.ncbi.nlm.nih.gov/pubmed/33975598
http://dx.doi.org/10.1186/s12935-021-01956-2
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