tRNA-derived fragments as novel potential biomarkers for relapsed/refractory multiple myeloma

BACKGROUND: tRNA-derived fragments have been reported to be key regulatory factors in human tumors. However, their roles in the progression of multiple myeloma remain unknown. RESULTS: This study employed RNA-sequencing to explore the expression profiles of tRFs/tiRNAs in new diagnosed MM and relaps...

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Detalles Bibliográficos
Autores principales: Xu, Cong, Liang, Ting, Zhang, Fangrong, Liu, Jing, Fu, Yunfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111751/
https://www.ncbi.nlm.nih.gov/pubmed/33971811
http://dx.doi.org/10.1186/s12859-021-04167-8
Descripción
Sumario:BACKGROUND: tRNA-derived fragments have been reported to be key regulatory factors in human tumors. However, their roles in the progression of multiple myeloma remain unknown. RESULTS: This study employed RNA-sequencing to explore the expression profiles of tRFs/tiRNAs in new diagnosed MM and relapsed/refractory MM samples. The expression of selected tRFs/tiRNAs were further validated in clinical specimens and myeloma cell lines by qPCR. Bioinformatic analysis was performed to predict their roles in multiple myeloma progression.We identified 10 upregulated tRFs/tiRNAs and 16 downregulated tRFs/tiRNAs. GO enrichment and KEGG pathway analysis were performed to analyse the functions of 1 significantly up-regulated and 1 significantly down-regulated tRNA-derived fragments. tRFs/tiRNAs may be involved in MM progression and drug-resistance. CONCLUSION: tRFs/tiRNAs were dysregulated and could be potential biomarkers for relapsed/refractory MM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12859-021-04167-8.

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