Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

Homozygous mutations in the lysosomal glucocerebrosidase gene, GBA1, cause Gaucher’s disease (GD), while heterozygous mutations in GBA1 are a strong risk factor for Parkinson’s disease (PD), whose pathological hallmark is intraneuronal α-synuclein (asyn) aggregates. We previously reported that gba1...

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Detalles Bibliográficos
Autores principales: Nakanishi, Etsuro, Uemura, Norihito, Akiyama, Hisako, Kinoshita, Masato, Masanori, Sawamura, Taruno, Yosuke, Yamakado, Hodaka, Matsuzawa, Shu-ichi, Takeda, Shunichi, Hirabayashi, Yoshio, Takahashi, Ryosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111776/
https://www.ncbi.nlm.nih.gov/pubmed/33971917
http://dx.doi.org/10.1186/s13041-021-00790-x

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