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Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis

The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between the gut and brain, and is increasingly recognized as playing a central role in physiology and disease. MicroRNAs are important intracellular components secreted by extracellular vesicles (EVs), which act as vital m...

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Bibliographic Details
Main Authors: Zhao, Liang, Ye, Yingze, Gu, Lijuan, Jian, Zhihong, Stary, Creed M., Xiong, Xiaoxing
Format: Online Article Text
Language:English
Published: BioMed Central 2021
Subjects:
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111782/
https://www.ncbi.nlm.nih.gov/pubmed/33975607
http://dx.doi.org/10.1186/s12967-021-02861-y
Description
Summary:The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between the gut and brain, and is increasingly recognized as playing a central role in physiology and disease. MicroRNAs are important intracellular components secreted by extracellular vesicles (EVs), which act as vital mediators of intercellular and interspecies communication. This review will present current advances in EV-derived microRNAs and their potential functional link with GBMAx. We propose that EV-derived microRNAs comprise a novel regulatory system for GBMAx, and a potential novel therapeutic target for modifying GBMAx in clinical therapy.