Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis

The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between the gut and brain, and is increasingly recognized as playing a central role in physiology and disease. MicroRNAs are important intracellular components secreted by extracellular vesicles (EVs), which act as vital m...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Liang, Ye, Yingze, Gu, Lijuan, Jian, Zhihong, Stary, Creed M., Xiong, Xiaoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111782/
https://www.ncbi.nlm.nih.gov/pubmed/33975607
http://dx.doi.org/10.1186/s12967-021-02861-y
_version_ 1783690569470443520
author Zhao, Liang
Ye, Yingze
Gu, Lijuan
Jian, Zhihong
Stary, Creed M.
Xiong, Xiaoxing
author_facet Zhao, Liang
Ye, Yingze
Gu, Lijuan
Jian, Zhihong
Stary, Creed M.
Xiong, Xiaoxing
author_sort Zhao, Liang
collection PubMed
description The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between the gut and brain, and is increasingly recognized as playing a central role in physiology and disease. MicroRNAs are important intracellular components secreted by extracellular vesicles (EVs), which act as vital mediators of intercellular and interspecies communication. This review will present current advances in EV-derived microRNAs and their potential functional link with GBMAx. We propose that EV-derived microRNAs comprise a novel regulatory system for GBMAx, and a potential novel therapeutic target for modifying GBMAx in clinical therapy.
format Online
Article
Text
id pubmed-8111782
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-81117822021-05-11 Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis Zhao, Liang Ye, Yingze Gu, Lijuan Jian, Zhihong Stary, Creed M. Xiong, Xiaoxing J Transl Med Review The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between the gut and brain, and is increasingly recognized as playing a central role in physiology and disease. MicroRNAs are important intracellular components secreted by extracellular vesicles (EVs), which act as vital mediators of intercellular and interspecies communication. This review will present current advances in EV-derived microRNAs and their potential functional link with GBMAx. We propose that EV-derived microRNAs comprise a novel regulatory system for GBMAx, and a potential novel therapeutic target for modifying GBMAx in clinical therapy. BioMed Central 2021-05-11 /pmc/articles/PMC8111782/ /pubmed/33975607 http://dx.doi.org/10.1186/s12967-021-02861-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhao, Liang
Ye, Yingze
Gu, Lijuan
Jian, Zhihong
Stary, Creed M.
Xiong, Xiaoxing
Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis
title Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis
title_full Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis
title_fullStr Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis
title_full_unstemmed Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis
title_short Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis
title_sort extracellular vesicle-derived mirna as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111782/
https://www.ncbi.nlm.nih.gov/pubmed/33975607
http://dx.doi.org/10.1186/s12967-021-02861-y
work_keys_str_mv AT zhaoliang extracellularvesiclederivedmirnaasanovelregulatorysystemforbidirectionalcommunicationingutbrainmicrobiotaaxis
AT yeyingze extracellularvesiclederivedmirnaasanovelregulatorysystemforbidirectionalcommunicationingutbrainmicrobiotaaxis
AT gulijuan extracellularvesiclederivedmirnaasanovelregulatorysystemforbidirectionalcommunicationingutbrainmicrobiotaaxis
AT jianzhihong extracellularvesiclederivedmirnaasanovelregulatorysystemforbidirectionalcommunicationingutbrainmicrobiotaaxis
AT starycreedm extracellularvesiclederivedmirnaasanovelregulatorysystemforbidirectionalcommunicationingutbrainmicrobiotaaxis
AT xiongxiaoxing extracellularvesiclederivedmirnaasanovelregulatorysystemforbidirectionalcommunicationingutbrainmicrobiotaaxis

Ejemplares similares