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Association between body fat and bone mineral density in non-obese post-menopausal women over 60 years old

BACKGROUND: Loss of bone mineral density is one of the most important complications of menopause. The results of studies about the relation between body fat and bone mineral density are controversial. The aim of this study was to determine the association between fat mass and bone mineral density on...

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Autores principales: Hosseini, Seyed Amirhossein, Hosseini, Seyed Reza, Ghadimi, Reza, Noreddini, Hajighorban, Bijani, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111810/
https://www.ncbi.nlm.nih.gov/pubmed/34012539
http://dx.doi.org/10.22088/cjim.12.2.200
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author Hosseini, Seyed Amirhossein
Hosseini, Seyed Reza
Ghadimi, Reza
Noreddini, Hajighorban
Bijani, Ali
author_facet Hosseini, Seyed Amirhossein
Hosseini, Seyed Reza
Ghadimi, Reza
Noreddini, Hajighorban
Bijani, Ali
author_sort Hosseini, Seyed Amirhossein
collection PubMed
description BACKGROUND: Loss of bone mineral density is one of the most important complications of menopause. The results of studies about the relation between body fat and bone mineral density are controversial. The aim of this study was to determine the association between fat mass and bone mineral density on non-obese post-menopausal elderly women. METHODS: This cross-sectional study is a part of the second phase of the Amirkola Health and Ageing Project (AHAP) that has been done on 356 elderly women with BMI of 18.5-30. Bone mineral density (BMD) and total body fat were measured using the Hologic Horizon-WI densitometer. Statistical tests were ANOVA, Pearson’s correlation coefficient and multiple linear regression and a p- value less than 0.05 was considered significant. RESULTS: The mean age of the participants was 70.22±7.34 and the mean age of menopause was 47.68±5.05. Women with highest fat mass had a greater spine, femur and whole-body BMD (p<0.0001). In this study, we observed a direct and positive significant correlation between body fat mass and BMD at spine (r=0.308), femur (r=0.420) and whole body (r=0.312) (p<0.0001). Adjusted linear regression showed positive effect of fat mass on BMD on all three anatomical sites especially in total femur (β=0.254, p<0.0001). CONCLUSION: This study showed a positive correlation between fat mass and bone mineral density at all sites in post-menopausal women.
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spelling pubmed-81118102021-05-18 Association between body fat and bone mineral density in non-obese post-menopausal women over 60 years old Hosseini, Seyed Amirhossein Hosseini, Seyed Reza Ghadimi, Reza Noreddini, Hajighorban Bijani, Ali Caspian J Intern Med Original Article BACKGROUND: Loss of bone mineral density is one of the most important complications of menopause. The results of studies about the relation between body fat and bone mineral density are controversial. The aim of this study was to determine the association between fat mass and bone mineral density on non-obese post-menopausal elderly women. METHODS: This cross-sectional study is a part of the second phase of the Amirkola Health and Ageing Project (AHAP) that has been done on 356 elderly women with BMI of 18.5-30. Bone mineral density (BMD) and total body fat were measured using the Hologic Horizon-WI densitometer. Statistical tests were ANOVA, Pearson’s correlation coefficient and multiple linear regression and a p- value less than 0.05 was considered significant. RESULTS: The mean age of the participants was 70.22±7.34 and the mean age of menopause was 47.68±5.05. Women with highest fat mass had a greater spine, femur and whole-body BMD (p<0.0001). In this study, we observed a direct and positive significant correlation between body fat mass and BMD at spine (r=0.308), femur (r=0.420) and whole body (r=0.312) (p<0.0001). Adjusted linear regression showed positive effect of fat mass on BMD on all three anatomical sites especially in total femur (β=0.254, p<0.0001). CONCLUSION: This study showed a positive correlation between fat mass and bone mineral density at all sites in post-menopausal women. Babol University of Medical Sciences 2021-03 /pmc/articles/PMC8111810/ /pubmed/34012539 http://dx.doi.org/10.22088/cjim.12.2.200 Text en Copyright © 2020, Babol University of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hosseini, Seyed Amirhossein
Hosseini, Seyed Reza
Ghadimi, Reza
Noreddini, Hajighorban
Bijani, Ali
Association between body fat and bone mineral density in non-obese post-menopausal women over 60 years old
title Association between body fat and bone mineral density in non-obese post-menopausal women over 60 years old
title_full Association between body fat and bone mineral density in non-obese post-menopausal women over 60 years old
title_fullStr Association between body fat and bone mineral density in non-obese post-menopausal women over 60 years old
title_full_unstemmed Association between body fat and bone mineral density in non-obese post-menopausal women over 60 years old
title_short Association between body fat and bone mineral density in non-obese post-menopausal women over 60 years old
title_sort association between body fat and bone mineral density in non-obese post-menopausal women over 60 years old
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111810/
https://www.ncbi.nlm.nih.gov/pubmed/34012539
http://dx.doi.org/10.22088/cjim.12.2.200
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