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Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia

Schizophrenia is a severe brain disorder characterized by certain types of delusion, hallucination and thought disorder. Studies have revealed impaired synaptic plasticity and reduced gamma-aminobutyric acid levels of the visual cortex in patients with schizophrenia. While previous work established...

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Autores principales: Mavroudis, Ioannis, Petrides, Foivos, Kazis, Dimitrios, Chatzikonstantinou, Symela, Karantali, Eleni, Ciobica, Alin, Iordache, Alin-Constantin, Dobrin, Romeo, Trus, Constantin, Njau, Samuel, Costa, Vasiliki, Baloyannis, Stavros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111868/
https://www.ncbi.nlm.nih.gov/pubmed/33986834
http://dx.doi.org/10.3892/etm.2021.10101
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author Mavroudis, Ioannis
Petrides, Foivos
Kazis, Dimitrios
Chatzikonstantinou, Symela
Karantali, Eleni
Ciobica, Alin
Iordache, Alin-Constantin
Dobrin, Romeo
Trus, Constantin
Njau, Samuel
Costa, Vasiliki
Baloyannis, Stavros
author_facet Mavroudis, Ioannis
Petrides, Foivos
Kazis, Dimitrios
Chatzikonstantinou, Symela
Karantali, Eleni
Ciobica, Alin
Iordache, Alin-Constantin
Dobrin, Romeo
Trus, Constantin
Njau, Samuel
Costa, Vasiliki
Baloyannis, Stavros
author_sort Mavroudis, Ioannis
collection PubMed
description Schizophrenia is a severe brain disorder characterized by certain types of delusion, hallucination and thought disorder. Studies have revealed impaired synaptic plasticity and reduced gamma-aminobutyric acid levels of the visual cortex in patients with schizophrenia. While previous work established a critical role for interneurons and cortical connectivity in the generation of hallucinations, the present study set out to examine the morphology of pyramidal cells and interneurons from layers 3 and 4 in the primary visual cortex from schizophrenic brains and to identify any dendritic and spinal alterations in comparison to normal control brains. The morphological and morphometric changes of the pyramidal cells and the interneurons of the visual cortices of 10 brains obtained from patients with schizophrenia, in comparison to 10 age-matched controls, were studied using the Golgi method and 3D neuronal reconstruction techniques. Analysis using the Golgi impregnation technique revealed a significant loss of distal dendritic segments, tortuous branches and varicosities and an overall restriction of the dendritic field in the brains of schizophrenic patients in both pyramidal cells and in aspiny interneurons. The present results may explain certain clinical phenomena associated with the visual cortex usually encountered in schizophrenia.
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spelling pubmed-81118682021-05-12 Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia Mavroudis, Ioannis Petrides, Foivos Kazis, Dimitrios Chatzikonstantinou, Symela Karantali, Eleni Ciobica, Alin Iordache, Alin-Constantin Dobrin, Romeo Trus, Constantin Njau, Samuel Costa, Vasiliki Baloyannis, Stavros Exp Ther Med Articles Schizophrenia is a severe brain disorder characterized by certain types of delusion, hallucination and thought disorder. Studies have revealed impaired synaptic plasticity and reduced gamma-aminobutyric acid levels of the visual cortex in patients with schizophrenia. While previous work established a critical role for interneurons and cortical connectivity in the generation of hallucinations, the present study set out to examine the morphology of pyramidal cells and interneurons from layers 3 and 4 in the primary visual cortex from schizophrenic brains and to identify any dendritic and spinal alterations in comparison to normal control brains. The morphological and morphometric changes of the pyramidal cells and the interneurons of the visual cortices of 10 brains obtained from patients with schizophrenia, in comparison to 10 age-matched controls, were studied using the Golgi method and 3D neuronal reconstruction techniques. Analysis using the Golgi impregnation technique revealed a significant loss of distal dendritic segments, tortuous branches and varicosities and an overall restriction of the dendritic field in the brains of schizophrenic patients in both pyramidal cells and in aspiny interneurons. The present results may explain certain clinical phenomena associated with the visual cortex usually encountered in schizophrenia. D.A. Spandidos 2021-07 2021-04-22 /pmc/articles/PMC8111868/ /pubmed/33986834 http://dx.doi.org/10.3892/etm.2021.10101 Text en Copyright: © Mavroudis et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Mavroudis, Ioannis
Petrides, Foivos
Kazis, Dimitrios
Chatzikonstantinou, Symela
Karantali, Eleni
Ciobica, Alin
Iordache, Alin-Constantin
Dobrin, Romeo
Trus, Constantin
Njau, Samuel
Costa, Vasiliki
Baloyannis, Stavros
Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia
title Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia
title_full Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia
title_fullStr Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia
title_full_unstemmed Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia
title_short Morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia
title_sort morphological alterations of the pyramidal and stellate cells of the visual cortex in schizophrenia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111868/
https://www.ncbi.nlm.nih.gov/pubmed/33986834
http://dx.doi.org/10.3892/etm.2021.10101
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