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Protective effects of halophyte complex extract against UVB-induced damage in human keratinocytes and the skin of hairless mice

Limonium tetragonum, Triglochin maritimum, Artemisia scoparia and red ginseng have been used as folk remedies for treating a variety of diseases. In the current study, the protective effects of halophyte and red ginseng against ultraviolet (UV)-induced skin damage were investigated. Halophyte red gi...

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Autores principales: Shin, Jae Young, Park, Ji Hyeon, Che, Denis Nchang, Kang, Hyun Ju, Cho, Byoung Ok, Lim, Yi Teak, Jang, Seon Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111875/
https://www.ncbi.nlm.nih.gov/pubmed/33986847
http://dx.doi.org/10.3892/etm.2021.10114
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author Shin, Jae Young
Park, Ji Hyeon
Che, Denis Nchang
Kang, Hyun Ju
Cho, Byoung Ok
Lim, Yi Teak
Jang, Seon Il
author_facet Shin, Jae Young
Park, Ji Hyeon
Che, Denis Nchang
Kang, Hyun Ju
Cho, Byoung Ok
Lim, Yi Teak
Jang, Seon Il
author_sort Shin, Jae Young
collection PubMed
description Limonium tetragonum, Triglochin maritimum, Artemisia scoparia and red ginseng have been used as folk remedies for treating a variety of diseases. In the current study, the protective effects of halophyte and red ginseng against ultraviolet (UV)-induced skin damage were investigated. Halophyte red ginseng complex extract (HRCE) was prepared and its effects on UV-B irradiated human keratinocytes and mouse skin were studied through ELISA, Western blotting immunofluorescence and histological staining. HRCE inhibited peroxide-induced damage in human keratinocytes. HRCE also inhibited UVB-induced collagen and elastin degradation in human keratinocytes and mouse skin. In addition, HRCE inhibited mast cell infiltration in the skin of mice irradiated with UVB light. This effect was likely due to HRCE inhibiting the activation of MAPK and NF-κB. By protecting the skin from UVB-induced skin damage, HRCE has the potential to be used in the treatment and prevention of UV-induced skin damage and photoaging.
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spelling pubmed-81118752021-05-12 Protective effects of halophyte complex extract against UVB-induced damage in human keratinocytes and the skin of hairless mice Shin, Jae Young Park, Ji Hyeon Che, Denis Nchang Kang, Hyun Ju Cho, Byoung Ok Lim, Yi Teak Jang, Seon Il Exp Ther Med Articles Limonium tetragonum, Triglochin maritimum, Artemisia scoparia and red ginseng have been used as folk remedies for treating a variety of diseases. In the current study, the protective effects of halophyte and red ginseng against ultraviolet (UV)-induced skin damage were investigated. Halophyte red ginseng complex extract (HRCE) was prepared and its effects on UV-B irradiated human keratinocytes and mouse skin were studied through ELISA, Western blotting immunofluorescence and histological staining. HRCE inhibited peroxide-induced damage in human keratinocytes. HRCE also inhibited UVB-induced collagen and elastin degradation in human keratinocytes and mouse skin. In addition, HRCE inhibited mast cell infiltration in the skin of mice irradiated with UVB light. This effect was likely due to HRCE inhibiting the activation of MAPK and NF-κB. By protecting the skin from UVB-induced skin damage, HRCE has the potential to be used in the treatment and prevention of UV-induced skin damage and photoaging. D.A. Spandidos 2021-07 2021-04-25 /pmc/articles/PMC8111875/ /pubmed/33986847 http://dx.doi.org/10.3892/etm.2021.10114 Text en Copyright: © Shin et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Shin, Jae Young
Park, Ji Hyeon
Che, Denis Nchang
Kang, Hyun Ju
Cho, Byoung Ok
Lim, Yi Teak
Jang, Seon Il
Protective effects of halophyte complex extract against UVB-induced damage in human keratinocytes and the skin of hairless mice
title Protective effects of halophyte complex extract against UVB-induced damage in human keratinocytes and the skin of hairless mice
title_full Protective effects of halophyte complex extract against UVB-induced damage in human keratinocytes and the skin of hairless mice
title_fullStr Protective effects of halophyte complex extract against UVB-induced damage in human keratinocytes and the skin of hairless mice
title_full_unstemmed Protective effects of halophyte complex extract against UVB-induced damage in human keratinocytes and the skin of hairless mice
title_short Protective effects of halophyte complex extract against UVB-induced damage in human keratinocytes and the skin of hairless mice
title_sort protective effects of halophyte complex extract against uvb-induced damage in human keratinocytes and the skin of hairless mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111875/
https://www.ncbi.nlm.nih.gov/pubmed/33986847
http://dx.doi.org/10.3892/etm.2021.10114
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