mTOR regulates GPVI-mediated platelet activation

BACKGROUND: Due to mTOR (mammalian/mechanistic target of rapamycin) gene-loss mice die during embryonic development, the role of mTOR in platelets has not been evaluated using gene knockout technology. METHODS: A mouse model with megakaryocyte/platelet-specific deletion of mTOR was established, and...

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Detalles Bibliográficos
Autores principales: Wang, Longsheng, Liu, Gang, Wu, Nannan, Dai, Baiyun, Han, Shuang, Liu, Qiaoyun, Huang, Fang, Chen, Zhihua, Xu, Weihong, Xia, Dajing, Gao, Cunji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111939/
https://www.ncbi.nlm.nih.gov/pubmed/33971888
http://dx.doi.org/10.1186/s12967-021-02756-y

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