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Super-resolution visualization and modeling of human chromosomal regions reveals cohesin-dependent loop structures
BACKGROUND: The 3D organization of the chromatin fiber in cell nuclei plays a key role in the regulation of gene expression. Genome-wide techniques to score DNA-DNA contacts, such as Hi-C, reveal the partitioning of chromosomes into epigenetically defined active and repressed compartments and smalle...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111965/ https://www.ncbi.nlm.nih.gov/pubmed/33975635 http://dx.doi.org/10.1186/s13059-021-02343-w |