Cargando…

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice

When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer’s disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the brain, Aβ exists as a pool of distinct C-terminal variants with le...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruiz-Riquelme, Alejandro, Mao, Alison, Barghash, Marim M., Lau, Heather H. C., Stuart, Erica, Kovacs, Gabor G., Nilsson, K. Peter R., Fraser, Paul E., Schmitt-Ulms, Gerold, Watts, Joel C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112054/ https://www.ncbi.nlm.nih.gov/pubmed/33971978 http://dx.doi.org/10.1186/s40478-021-01187-6

Ejemplares similares

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
por: Ruiz-Riquelme, Alejandro, et al.
Publicado: (2018)

Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters
por: Schmitt-Ulms, Gerold, et al.
Publicado: (2009)

NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being?
por: Mehrabian, Mohadeseh, et al.
Publicado: (2016)

PrionHome: A Database of Prions and Other Sequences Relevant to Prion Phenomena
por: Harbi, Djamel, et al.
Publicado: (2012)

Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein
por: Eid, Shehab, et al.
Publicado: (2022)

An emerging role of the cellular prion protein as a modulator of a morphogenetic program underlying epithelial-to-mesenchymal transition
por: Mehrabian, Mohadeseh, et al.
Publicado: (2014)

Overcoming barriers and thresholds – signaling of oligomeric Aβ through the prion protein to Fyn
por: Wang, Hansen, et al.
Publicado: (2013)

The aminoglycoside G418 hinders de novo prion infection in cultured cells
por: Arshad, Hamza, et al.
Publicado: (2021)

Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy
por: Katorcha, Elizaveta, et al.
Publicado: (2017)

Evidence for Retrogene Origins of the Prion Gene Family
por: Ehsani, Sepehr, et al.
Publicado: (2011)

The prion protein is embedded in a molecular environment that modulates transforming growth factor β and integrin signaling
por: Ghodrati, Farinaz, et al.
Publicado: (2018)

The cellular prion protein interacts with and promotes the activity of Na,K-ATPases
por: Williams, Declan, et al.
Publicado: (2021)

The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis
por: Mehrabian, Mohadeseh, et al.
Publicado: (2015)

CRISPR-Cas9-Based Knockout of the Prion Protein and Its Effect on the Proteome
por: Mehrabian, Mohadeseh, et al.
Publicado: (2014)

Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue
por: Mehrabian, Mohadeseh, et al.
Publicado: (2016)

Aggregation of Aβ(40/42) chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations
por: Wu, Min, et al.
Publicado: (2021)

Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43
por: Tanaka, Yoshinori, et al.
Publicado: (2016)

The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections
por: Watts, Joel C, et al.
Publicado: (2007)

Heterologous prion-forming proteins interact to cross-seed aggregation in Saccharomyces cerevisiae
por: Keefer, Kathryn M., et al.
Publicado: (2017)

A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS
por: Shenouda, Marc, et al.
Publicado: (2022)

Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases
por: Arnould, Hélène, et al.
Publicado: (2021)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

Liquid–Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation
por: Pakravan, Donya, et al.
Publicado: (2021)

Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage
por: Kumar, Senthil T., et al.
Publicado: (2023)

Molecular Mechanisms in the Pathogenesis of Alzheimer’s disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation
por: Hasegawa, Masato
Publicado: (2016)

The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease
por: Lau, Heather H. C., et al.
Publicado: (2023)

Cardiac glycoside-mediated turnover of Na, K-ATPases as a rational approach to reducing cell surface levels of the cellular prion protein
por: Mehrabian, Mohadeseh, et al.
Publicado: (2022)

The Evolutionary unZIPping of a Dimerization Motif—A Comparison of ZIP and PrP Architectures
por: Hu, Jian, et al.
Publicado: (2017)

Somatostatin slows Aβ plaque deposition in aged APP(NL-F/NL-F) mice by blocking Aβ aggregation
por: Williams, Declan, et al.
Publicado: (2023)

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo
por: Vasconcelos, Bruno, et al.
Publicado: (2016)

Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases
por: Isaacs, A M, et al.
Publicado: (2008)

Molecular Pathology of Human Prion Diseases
por: Kovacs, Gabor G., et al.
Publicado: (2009)

Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation
por: Lau, Agnes, et al.
Publicado: (2015)

Prion replication environment defines the fate of prion strain adaptation
por: Katorcha, Elizaveta, et al.
Publicado: (2018)

In vitro prion-like behaviour of TDP-43 in ALS
por: Smethurst, Phillip, et al.
Publicado: (2016)

The Role of Crowded Physiological Environments in Prion and Prion-like Protein Aggregation
por: Ma, Qian, et al.
Publicado: (2013)

Characteristic CSF Prion Seeding Efficiency in Humans with Prion Diseases
por: Cramm, Maria, et al.
Publicado: (2014)

Yeast Prions: Protein Aggregation Is Not Enough
por: Sherman, Michael Y
Publicado: (2004)

Immunopurification of Pathological Prion Protein Aggregates
por: Biasini, Emiliano, et al.
Publicado: (2009)

Role of Prion Protein Aggregation in Neurotoxicity
por: Corsaro, Alessandro, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qovpl5va38h52uttbn321ignte