Functional mapping of androgen receptor enhancer activity

BACKGROUND: Androgen receptor (AR) is critical to the initiation, growth, and progression of prostate cancer. Once activated, the AR binds to cis-regulatory enhancer elements on DNA that drive gene expression. Yet, there are 10–100× more binding sites than differentially expressed genes. It is uncle...

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Detalles Bibliográficos
Autores principales: Huang, Chia-Chi Flora, Lingadahalli, Shreyas, Morova, Tunc, Ozturan, Dogancan, Hu, Eugene, Yu, Ivan Pak Lok, Linder, Simon, Hoogstraat, Marlous, Stelloo, Suzan, Sar, Funda, van der Poel, Henk, Altintas, Umut Berkay, Saffarzadeh, Mohammadali, Le Bihan, Stephane, McConeghy, Brian, Gokbayrak, Bengul, Feng, Felix Y., Gleave, Martin E., Bergman, Andries M., Collins, Colin, Hach, Faraz, Zwart, Wilbert, Emberly, Eldon, Lack, Nathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112059/
https://www.ncbi.nlm.nih.gov/pubmed/33975627
http://dx.doi.org/10.1186/s13059-021-02339-6

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