Cargando…

Multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model

OBJECTIVES: We sought to analyze the hemodynamic effects of the multilayer flow-modulated stent (MFMS) in Thoracoabdominal aortic aneurysms (TAAAs). METHODS: The hemodynamic effects of MFMS were analyzed in aortic thoracoabdominal aneurysms in experimental swine models. We randomly assigned 18 pigs...

Descripción completa

Detalles Bibliográficos
Autores principales: Baptista-Strazzi, Anna Paula Weinhardt, Aun, Ricardo, Sincos, Igor Rafael, Tobita, Allana M., Portugal, Maria Fernanda Cassino, de Paula, Vitória Penido, Kaufmann, Oskar, Wolosker, Nelson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Medicina / USP 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112104/
https://www.ncbi.nlm.nih.gov/pubmed/34037071
http://dx.doi.org/10.6061/clinics/2021/e2812
_version_ 1783690625231618048
author Baptista-Strazzi, Anna Paula Weinhardt
Aun, Ricardo
Sincos, Igor Rafael
Tobita, Allana M.
Portugal, Maria Fernanda Cassino
de Paula, Vitória Penido
Kaufmann, Oskar
Wolosker, Nelson
author_facet Baptista-Strazzi, Anna Paula Weinhardt
Aun, Ricardo
Sincos, Igor Rafael
Tobita, Allana M.
Portugal, Maria Fernanda Cassino
de Paula, Vitória Penido
Kaufmann, Oskar
Wolosker, Nelson
author_sort Baptista-Strazzi, Anna Paula Weinhardt
collection PubMed
description OBJECTIVES: We sought to analyze the hemodynamic effects of the multilayer flow-modulated stent (MFMS) in Thoracoabdominal aortic aneurysms (TAAAs). METHODS: The hemodynamic effects of MFMS were analyzed in aortic thoracoabdominal aneurysms in experimental swine models. We randomly assigned 18 pigs to the stent or control groups and underwent the creation of an artificial bovine pericardium transrenal aneurysm. In the stent group, an MFMS (Cardiatis, Isnes, Belgium) was immediately implanted. After 4 weeks, we evaluated aneurysm sac thrombosis and renal branch patency by angiography, duplex scan, and morphological analysis. RESULTS: All the renal arteries remained patent after re-evaluation in both groups. Aneurysmal sac thrombosis was absent in the control group, whereas in the stent group it was present in 66.7% of aneurysmal sacs (p=0.061). The mean final aneurysm sac diameter was significantly lower in the stent group (mean estimated reduction, 6.90 mm; p=0.021). The proximal neck diameter decreased significantly in the stent group (mean difference, 2.51 mm; p=0.022) and grew significantly in the control group (mean difference, 3.02 mm; p=0.007). The distal neck diameter increased significantly in the control group (mean difference, 3.24 mm; p=0.017). There were no significant findings regarding distal neck measurements in the stent group. CONCLUSION: The MFMSs remained patent and did not obstruct the renal arteries within 4 weeks. In the stent group, the device was also associated with a significant decrease in aneurysmal sac diameter and a large proportion (albeit non-significant) of aneurysmal sac thrombosis.
format Online
Article
Text
id pubmed-8112104
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Faculdade de Medicina / USP
record_format MEDLINE/PubMed
spelling pubmed-81121042021-05-14 Multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model Baptista-Strazzi, Anna Paula Weinhardt Aun, Ricardo Sincos, Igor Rafael Tobita, Allana M. Portugal, Maria Fernanda Cassino de Paula, Vitória Penido Kaufmann, Oskar Wolosker, Nelson Clinics (Sao Paulo) Original Article OBJECTIVES: We sought to analyze the hemodynamic effects of the multilayer flow-modulated stent (MFMS) in Thoracoabdominal aortic aneurysms (TAAAs). METHODS: The hemodynamic effects of MFMS were analyzed in aortic thoracoabdominal aneurysms in experimental swine models. We randomly assigned 18 pigs to the stent or control groups and underwent the creation of an artificial bovine pericardium transrenal aneurysm. In the stent group, an MFMS (Cardiatis, Isnes, Belgium) was immediately implanted. After 4 weeks, we evaluated aneurysm sac thrombosis and renal branch patency by angiography, duplex scan, and morphological analysis. RESULTS: All the renal arteries remained patent after re-evaluation in both groups. Aneurysmal sac thrombosis was absent in the control group, whereas in the stent group it was present in 66.7% of aneurysmal sacs (p=0.061). The mean final aneurysm sac diameter was significantly lower in the stent group (mean estimated reduction, 6.90 mm; p=0.021). The proximal neck diameter decreased significantly in the stent group (mean difference, 2.51 mm; p=0.022) and grew significantly in the control group (mean difference, 3.02 mm; p=0.007). The distal neck diameter increased significantly in the control group (mean difference, 3.24 mm; p=0.017). There were no significant findings regarding distal neck measurements in the stent group. CONCLUSION: The MFMSs remained patent and did not obstruct the renal arteries within 4 weeks. In the stent group, the device was also associated with a significant decrease in aneurysmal sac diameter and a large proportion (albeit non-significant) of aneurysmal sac thrombosis. Faculdade de Medicina / USP 2021-05-11 2021 /pmc/articles/PMC8112104/ /pubmed/34037071 http://dx.doi.org/10.6061/clinics/2021/e2812 Text en Copyright © 2021 CLINICS https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.
spellingShingle Original Article
Baptista-Strazzi, Anna Paula Weinhardt
Aun, Ricardo
Sincos, Igor Rafael
Tobita, Allana M.
Portugal, Maria Fernanda Cassino
de Paula, Vitória Penido
Kaufmann, Oskar
Wolosker, Nelson
Multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model
title Multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model
title_full Multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model
title_fullStr Multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model
title_full_unstemmed Multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model
title_short Multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model
title_sort multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112104/
https://www.ncbi.nlm.nih.gov/pubmed/34037071
http://dx.doi.org/10.6061/clinics/2021/e2812
work_keys_str_mv AT baptistastrazziannapaulaweinhardt multilayerstentsaffectthefinaldiameterofaorticaneurysmsandmaintainrenalarterypatencyforashorttimeinaswineexperimentalmodel
AT aunricardo multilayerstentsaffectthefinaldiameterofaorticaneurysmsandmaintainrenalarterypatencyforashorttimeinaswineexperimentalmodel
AT sincosigorrafael multilayerstentsaffectthefinaldiameterofaorticaneurysmsandmaintainrenalarterypatencyforashorttimeinaswineexperimentalmodel
AT tobitaallanam multilayerstentsaffectthefinaldiameterofaorticaneurysmsandmaintainrenalarterypatencyforashorttimeinaswineexperimentalmodel
AT portugalmariafernandacassino multilayerstentsaffectthefinaldiameterofaorticaneurysmsandmaintainrenalarterypatencyforashorttimeinaswineexperimentalmodel
AT depaulavitoriapenido multilayerstentsaffectthefinaldiameterofaorticaneurysmsandmaintainrenalarterypatencyforashorttimeinaswineexperimentalmodel
AT kaufmannoskar multilayerstentsaffectthefinaldiameterofaorticaneurysmsandmaintainrenalarterypatencyforashorttimeinaswineexperimentalmodel
AT woloskernelson multilayerstentsaffectthefinaldiameterofaorticaneurysmsandmaintainrenalarterypatencyforashorttimeinaswineexperimentalmodel