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Developmental Toxicity of the Neural Tube Induced by Titanium Dioxide Nanoparticles in Mouse Embryos

BACKGROUND: This study investigated the potential effects of Titanium dioxide nanoparticles (Tio2NPs) followed by maternal gavage on fetal development and neural tube formation during pregnancy in mice. METHODS: Thirty pregnant mice were randomly divided into five main study groups including the unt...

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Autores principales: Mohamadzadeh, Nahid, Zirak Javanmard, Masoumeh, Karimipour, Mojtaba, Farjah, Gholamhosain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112145/
https://www.ncbi.nlm.nih.gov/pubmed/34012522
http://dx.doi.org/10.18502/ajmb.v13i2.5524
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author Mohamadzadeh, Nahid
Zirak Javanmard, Masoumeh
Karimipour, Mojtaba
Farjah, Gholamhosain
author_facet Mohamadzadeh, Nahid
Zirak Javanmard, Masoumeh
Karimipour, Mojtaba
Farjah, Gholamhosain
author_sort Mohamadzadeh, Nahid
collection PubMed
description BACKGROUND: This study investigated the potential effects of Titanium dioxide nanoparticles (Tio2NPs) followed by maternal gavage on fetal development and neural tube formation during pregnancy in mice. METHODS: Thirty pregnant mice were randomly divided into five main study groups including the untreated control and 4 experimental groups (n=6 per group). The control group was treated with normal saline and the experimental groups were orally treated with doses of 30, 150, 300, and 500 mg/kg Body Weight (BW) of Tio2NPs during pregnancy. On gestational day 16 and 19 (n=3 per group), pregnant mice were euthanized and then examined for neural tube defects and compared with control. Serial transverse sections were prepared in both cranial region and in lumbar region of spinal cord. RESULTS: Treatment with Tio2NPs resulted in low fetal weight and short length, dilation of lateral ventricle, thinning of cerebral cortex and spinal cord, spina bifida occulta and an increase in the number of apoptotic neurons in exposed embryos at doses of 300 and 500 mg/kg (p<0.05). CONCLUSION: It seems that exposure to nanoparticles of Tio2 during pregnancy induces growth retardation and for the first time, teratogenicity of this nanomaterial in neural tube development and induction of defects such as spinal bifida, reduction in cortical thickness and dilatation of lateral ventricles were verified which can be related to incidence of apoptosis in central nervous system.
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spelling pubmed-81121452021-05-18 Developmental Toxicity of the Neural Tube Induced by Titanium Dioxide Nanoparticles in Mouse Embryos Mohamadzadeh, Nahid Zirak Javanmard, Masoumeh Karimipour, Mojtaba Farjah, Gholamhosain Avicenna J Med Biotechnol Original Article BACKGROUND: This study investigated the potential effects of Titanium dioxide nanoparticles (Tio2NPs) followed by maternal gavage on fetal development and neural tube formation during pregnancy in mice. METHODS: Thirty pregnant mice were randomly divided into five main study groups including the untreated control and 4 experimental groups (n=6 per group). The control group was treated with normal saline and the experimental groups were orally treated with doses of 30, 150, 300, and 500 mg/kg Body Weight (BW) of Tio2NPs during pregnancy. On gestational day 16 and 19 (n=3 per group), pregnant mice were euthanized and then examined for neural tube defects and compared with control. Serial transverse sections were prepared in both cranial region and in lumbar region of spinal cord. RESULTS: Treatment with Tio2NPs resulted in low fetal weight and short length, dilation of lateral ventricle, thinning of cerebral cortex and spinal cord, spina bifida occulta and an increase in the number of apoptotic neurons in exposed embryos at doses of 300 and 500 mg/kg (p<0.05). CONCLUSION: It seems that exposure to nanoparticles of Tio2 during pregnancy induces growth retardation and for the first time, teratogenicity of this nanomaterial in neural tube development and induction of defects such as spinal bifida, reduction in cortical thickness and dilatation of lateral ventricles were verified which can be related to incidence of apoptosis in central nervous system. Avicenna Research Institute 2021 /pmc/articles/PMC8112145/ /pubmed/34012522 http://dx.doi.org/10.18502/ajmb.v13i2.5524 Text en Copyright© 2021 Avicenna Research Institute https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Original Article
Mohamadzadeh, Nahid
Zirak Javanmard, Masoumeh
Karimipour, Mojtaba
Farjah, Gholamhosain
Developmental Toxicity of the Neural Tube Induced by Titanium Dioxide Nanoparticles in Mouse Embryos
title Developmental Toxicity of the Neural Tube Induced by Titanium Dioxide Nanoparticles in Mouse Embryos
title_full Developmental Toxicity of the Neural Tube Induced by Titanium Dioxide Nanoparticles in Mouse Embryos
title_fullStr Developmental Toxicity of the Neural Tube Induced by Titanium Dioxide Nanoparticles in Mouse Embryos
title_full_unstemmed Developmental Toxicity of the Neural Tube Induced by Titanium Dioxide Nanoparticles in Mouse Embryos
title_short Developmental Toxicity of the Neural Tube Induced by Titanium Dioxide Nanoparticles in Mouse Embryos
title_sort developmental toxicity of the neural tube induced by titanium dioxide nanoparticles in mouse embryos
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112145/
https://www.ncbi.nlm.nih.gov/pubmed/34012522
http://dx.doi.org/10.18502/ajmb.v13i2.5524
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