Resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces

We designed and synthesized two resorcin[4]arene scaffolds with four phosphate binding groups. The ligands effectively bind in at least a tridentate fashion at low surface coverage. The superior binding affinity is demonstrated using solution NMR spectroscopy and exceeds that of single phosphonates.

Detalles Bibliográficos
Autores principales: Nemat, Suren J., Van den Eynden, Dietger, Deblock, Loren, Heilmann, Michael, Köster, Jesper M., Parvizian, Mahsa, Tiefenbacher, Konrad, De Roo, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112235/
https://www.ncbi.nlm.nih.gov/pubmed/33977984
http://dx.doi.org/10.1039/d1cc00223f
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author Nemat, Suren J.
Van den Eynden, Dietger
Deblock, Loren
Heilmann, Michael
Köster, Jesper M.
Parvizian, Mahsa
Tiefenbacher, Konrad
De Roo, Jonathan
author_facet Nemat, Suren J.
Van den Eynden, Dietger
Deblock, Loren
Heilmann, Michael
Köster, Jesper M.
Parvizian, Mahsa
Tiefenbacher, Konrad
De Roo, Jonathan
author_sort Nemat, Suren J.
collection PubMed
description We designed and synthesized two resorcin[4]arene scaffolds with four phosphate binding groups. The ligands effectively bind in at least a tridentate fashion at low surface coverage. The superior binding affinity is demonstrated using solution NMR spectroscopy and exceeds that of single phosphonates.
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spelling pubmed-81122352021-06-02 Resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces Nemat, Suren J. Van den Eynden, Dietger Deblock, Loren Heilmann, Michael Köster, Jesper M. Parvizian, Mahsa Tiefenbacher, Konrad De Roo, Jonathan Chem Commun (Camb) Chemistry We designed and synthesized two resorcin[4]arene scaffolds with four phosphate binding groups. The ligands effectively bind in at least a tridentate fashion at low surface coverage. The superior binding affinity is demonstrated using solution NMR spectroscopy and exceeds that of single phosphonates. The Royal Society of Chemistry 2021-04-13 /pmc/articles/PMC8112235/ /pubmed/33977984 http://dx.doi.org/10.1039/d1cc00223f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Nemat, Suren J.
Van den Eynden, Dietger
Deblock, Loren
Heilmann, Michael
Köster, Jesper M.
Parvizian, Mahsa
Tiefenbacher, Konrad
De Roo, Jonathan
Resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces
title Resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces
title_full Resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces
title_fullStr Resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces
title_full_unstemmed Resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces
title_short Resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces
title_sort resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112235/
https://www.ncbi.nlm.nih.gov/pubmed/33977984
http://dx.doi.org/10.1039/d1cc00223f
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