Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning

A key hurdle to making adeno-associated virus (AAV) capsid mediated gene therapy broadly beneficial to all patients is overcoming pre-existing and therapy-induced immune responses to these vectors. Recent advances in high-throughput DNA synthesis, multiplexing and sequencing technologies have accele...

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Detalles Bibliográficos
Autores principales: Wec, Anna Z., Lin, Kathy S., Kwasnieski, Jamie C., Sinai, Sam, Gerold, Jeff, Kelsic, Eric D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112259/
https://www.ncbi.nlm.nih.gov/pubmed/33986759
http://dx.doi.org/10.3389/fimmu.2021.674021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112259/
https://www.ncbi.nlm.nih.gov/pubmed/33986759
http://dx.doi.org/10.3389/fimmu.2021.674021

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