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Scoring system for identifying Japanese patients with COVID-19 at risk of requiring oxygen supply: A retrospective single-center study
INTRODUCTION: Japan is facing the threat of medical system collapse due to the rapid spread of coronavirus disease 2019 (COVID-19). The present scoring system may help assess disease severity and oxygen supply requirements in COVID-19 patients. METHODS: Data on patient characteristics at baseline an...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112289/ https://www.ncbi.nlm.nih.gov/pubmed/34023221 http://dx.doi.org/10.1016/j.jiac.2021.05.002 |
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author | Kitajima, Heita Hirashima, Tomonori Suzuki, Hidekazu Arai, Tsuyoshi Tamura, Yoshitaka Hashimoto, Shoji Morishita, Hiroshi Matsuoka, Hiroto Kashiwa, Yozo Han, Yuki Minamoto, Seijiro Tanaka, Toshio Nagai, Takayuki |
author_facet | Kitajima, Heita Hirashima, Tomonori Suzuki, Hidekazu Arai, Tsuyoshi Tamura, Yoshitaka Hashimoto, Shoji Morishita, Hiroshi Matsuoka, Hiroto Kashiwa, Yozo Han, Yuki Minamoto, Seijiro Tanaka, Toshio Nagai, Takayuki |
author_sort | Kitajima, Heita |
collection | PubMed |
description | INTRODUCTION: Japan is facing the threat of medical system collapse due to the rapid spread of coronavirus disease 2019 (COVID-19). The present scoring system may help assess disease severity and oxygen supply requirements in COVID-19 patients. METHODS: Data on patient characteristics at baseline and throughout hospitalization for COVID-19 were extracted from medical records. Disease severity was dichotomized into two categories without or with oxygen supply as asymptomatic, mild, and moderate illness (AMMI), and severe and critical illness (CSI). The AMMI and CSI groups were compared. Predictors of disease severity, previously identified in the outpatient setting, were included in multivariable logistic regression analysis; the obtained coefficients were converted to integers and assigned a score. RESULTS: A total of 206 patients diagnosed with COVID-19 were included in this study. Correlation between COVID-19 severity and medical information was examined by comparing AMMI and CSI. Age, hemodialysis, and C-reactive protein (CRP) levels were candidate predictors of the need for oxygen supply in patients with COVID-19. Coefficients associated with age, hemodialysis, and CRP were as follows: 1 × age (in years, coded as 0 for values of <50, and as 1 for values of ≥50) + 1 × hemodialysis (coded as 0 for “no”, and as 1 for “yes”) + 1 × CRP (in mg/dL, coded as 0 for values of <1.0, and as 1 for values of ≥1.0). Patients with scores of ≥2 points required oxygen supply (sensitivity, 68.4%; specificity, 79.0%) CONCLUSION: The present model can help predict disease severity and oxygen requirements in COVID-19 patients in Japan. |
format | Online Article Text |
id | pubmed-8112289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81122892021-05-11 Scoring system for identifying Japanese patients with COVID-19 at risk of requiring oxygen supply: A retrospective single-center study Kitajima, Heita Hirashima, Tomonori Suzuki, Hidekazu Arai, Tsuyoshi Tamura, Yoshitaka Hashimoto, Shoji Morishita, Hiroshi Matsuoka, Hiroto Kashiwa, Yozo Han, Yuki Minamoto, Seijiro Tanaka, Toshio Nagai, Takayuki J Infect Chemother Original Article INTRODUCTION: Japan is facing the threat of medical system collapse due to the rapid spread of coronavirus disease 2019 (COVID-19). The present scoring system may help assess disease severity and oxygen supply requirements in COVID-19 patients. METHODS: Data on patient characteristics at baseline and throughout hospitalization for COVID-19 were extracted from medical records. Disease severity was dichotomized into two categories without or with oxygen supply as asymptomatic, mild, and moderate illness (AMMI), and severe and critical illness (CSI). The AMMI and CSI groups were compared. Predictors of disease severity, previously identified in the outpatient setting, were included in multivariable logistic regression analysis; the obtained coefficients were converted to integers and assigned a score. RESULTS: A total of 206 patients diagnosed with COVID-19 were included in this study. Correlation between COVID-19 severity and medical information was examined by comparing AMMI and CSI. Age, hemodialysis, and C-reactive protein (CRP) levels were candidate predictors of the need for oxygen supply in patients with COVID-19. Coefficients associated with age, hemodialysis, and CRP were as follows: 1 × age (in years, coded as 0 for values of <50, and as 1 for values of ≥50) + 1 × hemodialysis (coded as 0 for “no”, and as 1 for “yes”) + 1 × CRP (in mg/dL, coded as 0 for values of <1.0, and as 1 for values of ≥1.0). Patients with scores of ≥2 points required oxygen supply (sensitivity, 68.4%; specificity, 79.0%) CONCLUSION: The present model can help predict disease severity and oxygen requirements in COVID-19 patients in Japan. Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2021-08 2021-05-11 /pmc/articles/PMC8112289/ /pubmed/34023221 http://dx.doi.org/10.1016/j.jiac.2021.05.002 Text en © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Kitajima, Heita Hirashima, Tomonori Suzuki, Hidekazu Arai, Tsuyoshi Tamura, Yoshitaka Hashimoto, Shoji Morishita, Hiroshi Matsuoka, Hiroto Kashiwa, Yozo Han, Yuki Minamoto, Seijiro Tanaka, Toshio Nagai, Takayuki Scoring system for identifying Japanese patients with COVID-19 at risk of requiring oxygen supply: A retrospective single-center study |
title | Scoring system for identifying Japanese patients with COVID-19 at risk of requiring oxygen supply: A retrospective single-center study |
title_full | Scoring system for identifying Japanese patients with COVID-19 at risk of requiring oxygen supply: A retrospective single-center study |
title_fullStr | Scoring system for identifying Japanese patients with COVID-19 at risk of requiring oxygen supply: A retrospective single-center study |
title_full_unstemmed | Scoring system for identifying Japanese patients with COVID-19 at risk of requiring oxygen supply: A retrospective single-center study |
title_short | Scoring system for identifying Japanese patients with COVID-19 at risk of requiring oxygen supply: A retrospective single-center study |
title_sort | scoring system for identifying japanese patients with covid-19 at risk of requiring oxygen supply: a retrospective single-center study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112289/ https://www.ncbi.nlm.nih.gov/pubmed/34023221 http://dx.doi.org/10.1016/j.jiac.2021.05.002 |
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