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A mathematical model to optimize the available control measures of COVID – 19
In the absence of valid medicine or vaccine for treating the pandemic Coronavirus (COVID-19) infection, other control strategies like; quarantine, social distancing, self- isolation, sanitation and use of personal protective equipment are effective tool used to prevent and curtail the spread of the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112299/ http://dx.doi.org/10.1016/j.ecocom.2021.100930 |
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author | Baba, Isa Abdullahi Nasidi, Bashir Ahmad Baleanu, Dumitru Saadi, Sultan Hamed |
author_facet | Baba, Isa Abdullahi Nasidi, Bashir Ahmad Baleanu, Dumitru Saadi, Sultan Hamed |
author_sort | Baba, Isa Abdullahi |
collection | PubMed |
description | In the absence of valid medicine or vaccine for treating the pandemic Coronavirus (COVID-19) infection, other control strategies like; quarantine, social distancing, self- isolation, sanitation and use of personal protective equipment are effective tool used to prevent and curtail the spread of the disease. In this paper, we present a mathematical model to study the dynamics of COVID-19. We then formulate an optimal control problem with the aim to study the most effective control strategies to prevent the proliferation of the disease. The existence of an optimal control function is established and the Pontryagin maximum principle is applied for the characterization of the controller. The equilibrium solutions (DFE & endemic) are found to be locally asymptotically stable and subsequently the basic reproduction number is obtained. Numerical simulations are carried out to support the analytic results and to explicitly show the significance of the control. It is shown that Quarantine/isolating those infected with the disease is the best control measure at the moment. |
format | Online Article Text |
id | pubmed-8112299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81122992021-05-11 A mathematical model to optimize the available control measures of COVID – 19 Baba, Isa Abdullahi Nasidi, Bashir Ahmad Baleanu, Dumitru Saadi, Sultan Hamed Ecological Complexity Article In the absence of valid medicine or vaccine for treating the pandemic Coronavirus (COVID-19) infection, other control strategies like; quarantine, social distancing, self- isolation, sanitation and use of personal protective equipment are effective tool used to prevent and curtail the spread of the disease. In this paper, we present a mathematical model to study the dynamics of COVID-19. We then formulate an optimal control problem with the aim to study the most effective control strategies to prevent the proliferation of the disease. The existence of an optimal control function is established and the Pontryagin maximum principle is applied for the characterization of the controller. The equilibrium solutions (DFE & endemic) are found to be locally asymptotically stable and subsequently the basic reproduction number is obtained. Numerical simulations are carried out to support the analytic results and to explicitly show the significance of the control. It is shown that Quarantine/isolating those infected with the disease is the best control measure at the moment. Elsevier B.V. 2021-03 2021-05-11 /pmc/articles/PMC8112299/ http://dx.doi.org/10.1016/j.ecocom.2021.100930 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Baba, Isa Abdullahi Nasidi, Bashir Ahmad Baleanu, Dumitru Saadi, Sultan Hamed A mathematical model to optimize the available control measures of COVID – 19 |
title | A mathematical model to optimize the available control measures of COVID – 19 |
title_full | A mathematical model to optimize the available control measures of COVID – 19 |
title_fullStr | A mathematical model to optimize the available control measures of COVID – 19 |
title_full_unstemmed | A mathematical model to optimize the available control measures of COVID – 19 |
title_short | A mathematical model to optimize the available control measures of COVID – 19 |
title_sort | mathematical model to optimize the available control measures of covid – 19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112299/ http://dx.doi.org/10.1016/j.ecocom.2021.100930 |
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