Cargando…
Active-Site Models of Streptococcus pyogenes Cas9 in DNA Cleavage State
CRISPR-Cas9 is a powerful tool for target genome editing in living cells. Significant advances have been made to understand how this system cleaves target DNA. However, due to difficulty in determining active CRISPR-Cas9 structure in DNA cleavage state by X-ray and cryo-EM, it remains uncertain how...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112549/ https://www.ncbi.nlm.nih.gov/pubmed/33987202 http://dx.doi.org/10.3389/fmolb.2021.653262 |