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Metaplastic Breast Carcinoma: Clinicopathological Parameters and Prognostic Profile
Introduction Metaplastic breast carcinoma (MBC) is defined as breast cancer with a heterologous non-glandular component. MBC is considered a special type of breast cancer with a prognosis that is worse than invasive ductal carcinoma (IDC) of the breast. MBC is the most common breast cancer with a tr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112600/ https://www.ncbi.nlm.nih.gov/pubmed/33987039 http://dx.doi.org/10.7759/cureus.14347 |
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author | Haroon, Saroona Zia, Shamail Shirazi, Umme Aiman Ahmed, Omer Asghar, Ishaq Azeem Diwan, Muhammad Asad Afzal, Anoshia Irfan, Muhammad Ali, Syed Jawwad Hashmi, Atif A |
author_facet | Haroon, Saroona Zia, Shamail Shirazi, Umme Aiman Ahmed, Omer Asghar, Ishaq Azeem Diwan, Muhammad Asad Afzal, Anoshia Irfan, Muhammad Ali, Syed Jawwad Hashmi, Atif A |
author_sort | Haroon, Saroona |
collection | PubMed |
description | Introduction Metaplastic breast carcinoma (MBC) is defined as breast cancer with a heterologous non-glandular component. MBC is considered a special type of breast cancer with a prognosis that is worse than invasive ductal carcinoma (IDC) of the breast. MBC is the most common breast cancer with a triple-negative profile. Therefore, in this study, we evaluated the clinicopathological parameters, recurrence and survival of MBC in our population. Methods We conducted a retrospective observational study in the Department of Histopathology at Prince Faisal Oncology Centre, Buraidah, Saudi Arabia, over a period of five years. All cases diagnosed as MBC were included in the study. Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu) immunohistochemistry (IHC) was performed on representative tissue blocks. Results Total 183 cases of MBCs were included in the study, out of which 120 cases were excision specimens. The mean age of the patients was 48.84±12.99 years, and the most common age group was between 36 and 50 years of age. Most of the cases were tumor (T) stage T3 (50%), and nodal metastasis was present in 40% of cases. Most cases were grade III (78.7%). ER, PR and HER2/neu positivity was noted in 15.8%, 13.1%, and 9.8% cases, respectively. Follow-up data were available for 70 cases, with a median follow-up period of 4 (1-7) years. Tumor recurrence was noted in 31.4% cases, with a survival rate of 71.4%. Squamous, chondroid, spindle cell differentiation, and matrix production were noted in 70.5%, 7.1%, 13.7%, and 2.2% cases, respectively. A significant association of squamous differentiation was noted with HER2/neu positivity. An inverse association of spindle cell differentiation was seen with axillary metastasis. Survival analysis by Kaplan-Meier revealed a significant association of survival with tumor recurrence. Conclusion MBC is an important subtype of breast cancer, histopathological identification of which is challenging, owing to varied histological differentiation. We found squamous differentiation to be the most common in MBC, which was associated with HER2/neu positivity. A high recurrence rate of MBC was also observed in our study that was significantly associated with survival. |
format | Online Article Text |
id | pubmed-8112600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-81126002021-05-12 Metaplastic Breast Carcinoma: Clinicopathological Parameters and Prognostic Profile Haroon, Saroona Zia, Shamail Shirazi, Umme Aiman Ahmed, Omer Asghar, Ishaq Azeem Diwan, Muhammad Asad Afzal, Anoshia Irfan, Muhammad Ali, Syed Jawwad Hashmi, Atif A Cureus Pathology Introduction Metaplastic breast carcinoma (MBC) is defined as breast cancer with a heterologous non-glandular component. MBC is considered a special type of breast cancer with a prognosis that is worse than invasive ductal carcinoma (IDC) of the breast. MBC is the most common breast cancer with a triple-negative profile. Therefore, in this study, we evaluated the clinicopathological parameters, recurrence and survival of MBC in our population. Methods We conducted a retrospective observational study in the Department of Histopathology at Prince Faisal Oncology Centre, Buraidah, Saudi Arabia, over a period of five years. All cases diagnosed as MBC were included in the study. Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu) immunohistochemistry (IHC) was performed on representative tissue blocks. Results Total 183 cases of MBCs were included in the study, out of which 120 cases were excision specimens. The mean age of the patients was 48.84±12.99 years, and the most common age group was between 36 and 50 years of age. Most of the cases were tumor (T) stage T3 (50%), and nodal metastasis was present in 40% of cases. Most cases were grade III (78.7%). ER, PR and HER2/neu positivity was noted in 15.8%, 13.1%, and 9.8% cases, respectively. Follow-up data were available for 70 cases, with a median follow-up period of 4 (1-7) years. Tumor recurrence was noted in 31.4% cases, with a survival rate of 71.4%. Squamous, chondroid, spindle cell differentiation, and matrix production were noted in 70.5%, 7.1%, 13.7%, and 2.2% cases, respectively. A significant association of squamous differentiation was noted with HER2/neu positivity. An inverse association of spindle cell differentiation was seen with axillary metastasis. Survival analysis by Kaplan-Meier revealed a significant association of survival with tumor recurrence. Conclusion MBC is an important subtype of breast cancer, histopathological identification of which is challenging, owing to varied histological differentiation. We found squamous differentiation to be the most common in MBC, which was associated with HER2/neu positivity. A high recurrence rate of MBC was also observed in our study that was significantly associated with survival. Cureus 2021-04-07 /pmc/articles/PMC8112600/ /pubmed/33987039 http://dx.doi.org/10.7759/cureus.14347 Text en Copyright © 2021, Haroon et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pathology Haroon, Saroona Zia, Shamail Shirazi, Umme Aiman Ahmed, Omer Asghar, Ishaq Azeem Diwan, Muhammad Asad Afzal, Anoshia Irfan, Muhammad Ali, Syed Jawwad Hashmi, Atif A Metaplastic Breast Carcinoma: Clinicopathological Parameters and Prognostic Profile |
title | Metaplastic Breast Carcinoma: Clinicopathological Parameters and Prognostic Profile |
title_full | Metaplastic Breast Carcinoma: Clinicopathological Parameters and Prognostic Profile |
title_fullStr | Metaplastic Breast Carcinoma: Clinicopathological Parameters and Prognostic Profile |
title_full_unstemmed | Metaplastic Breast Carcinoma: Clinicopathological Parameters and Prognostic Profile |
title_short | Metaplastic Breast Carcinoma: Clinicopathological Parameters and Prognostic Profile |
title_sort | metaplastic breast carcinoma: clinicopathological parameters and prognostic profile |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112600/ https://www.ncbi.nlm.nih.gov/pubmed/33987039 http://dx.doi.org/10.7759/cureus.14347 |
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