Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population

Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected c...

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Autores principales: Yang, Guangzhi, Wang, Boshen, Sun, Dawei, Wang, Huimin, Chen, Mengyao, Chen, Hao, Zhu, Baoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112696/
https://www.ncbi.nlm.nih.gov/pubmed/33974633
http://dx.doi.org/10.1371/journal.pone.0251090
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author Yang, Guangzhi
Wang, Boshen
Sun, Dawei
Wang, Huimin
Chen, Mengyao
Chen, Hao
Zhu, Baoli
author_facet Yang, Guangzhi
Wang, Boshen
Sun, Dawei
Wang, Huimin
Chen, Mengyao
Chen, Hao
Zhu, Baoli
author_sort Yang, Guangzhi
collection PubMed
description Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future.
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spelling pubmed-81126962021-05-24 Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population Yang, Guangzhi Wang, Boshen Sun, Dawei Wang, Huimin Chen, Mengyao Chen, Hao Zhu, Baoli PLoS One Research Article Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future. Public Library of Science 2021-05-11 /pmc/articles/PMC8112696/ /pubmed/33974633 http://dx.doi.org/10.1371/journal.pone.0251090 Text en © 2021 Yang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yang, Guangzhi
Wang, Boshen
Sun, Dawei
Wang, Huimin
Chen, Mengyao
Chen, Hao
Zhu, Baoli
Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population
title Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population
title_full Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population
title_fullStr Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population
title_full_unstemmed Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population
title_short Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population
title_sort genetic association study between tab2 polymorphisms and noise-induced-hearing-loss in a han chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112696/
https://www.ncbi.nlm.nih.gov/pubmed/33974633
http://dx.doi.org/10.1371/journal.pone.0251090
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