Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology

Hepatic stellate cell (HSC), initially analyzed by von Kupffer, in 1876, revealed to be an extraordinary mesenchymal cell, essential for both hepatocellular function and lesions, being the hallmark of hepatic fibrogenesis and carcinogenesis. Apart from their implications in hepatic injury, HSCs play...

Descripción completa

Detalles Bibliográficos
Autores principales: Sufleţel, Rada-Teodora, Melincovici, Carmen Stanca, Gheban, Bogdan-Alexandru, Toader, Zaharie, Mihu, Carmen Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112759/
https://www.ncbi.nlm.nih.gov/pubmed/33817704
http://dx.doi.org/10.47162/RJME.61.3.01
_version_ 1783690731971411968
author Sufleţel, Rada-Teodora
Melincovici, Carmen Stanca
Gheban, Bogdan-Alexandru
Toader, Zaharie
Mihu, Carmen Mihaela
author_facet Sufleţel, Rada-Teodora
Melincovici, Carmen Stanca
Gheban, Bogdan-Alexandru
Toader, Zaharie
Mihu, Carmen Mihaela
author_sort Sufleţel, Rada-Teodora
collection PubMed
description Hepatic stellate cell (HSC), initially analyzed by von Kupffer, in 1876, revealed to be an extraordinary mesenchymal cell, essential for both hepatocellular function and lesions, being the hallmark of hepatic fibrogenesis and carcinogenesis. Apart from their implications in hepatic injury, HSCs play a vital role in liver development and regeneration, xenobiotic response, intermediate metabolism, and regulation of immune response. In this review, we discuss the current state of knowledge regarding HSCs morphology, human HSCs markers and human HSC cell lines. We also summarize the latest findings concerning their roles in normal and liver pathology, focusing on their impact in fibrogenesis, chronic viral hepatitis and liver tumors.
format Online
Article
Text
id pubmed-8112759
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest
record_format MEDLINE/PubMed
spelling pubmed-81127592021-06-01 Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology Sufleţel, Rada-Teodora Melincovici, Carmen Stanca Gheban, Bogdan-Alexandru Toader, Zaharie Mihu, Carmen Mihaela Rom J Morphol Embryol Review Hepatic stellate cell (HSC), initially analyzed by von Kupffer, in 1876, revealed to be an extraordinary mesenchymal cell, essential for both hepatocellular function and lesions, being the hallmark of hepatic fibrogenesis and carcinogenesis. Apart from their implications in hepatic injury, HSCs play a vital role in liver development and regeneration, xenobiotic response, intermediate metabolism, and regulation of immune response. In this review, we discuss the current state of knowledge regarding HSCs morphology, human HSCs markers and human HSC cell lines. We also summarize the latest findings concerning their roles in normal and liver pathology, focusing on their impact in fibrogenesis, chronic viral hepatitis and liver tumors. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2021-03-26 /pmc/articles/PMC8112759/ /pubmed/33817704 http://dx.doi.org/10.47162/RJME.61.3.01 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Review
Sufleţel, Rada-Teodora
Melincovici, Carmen Stanca
Gheban, Bogdan-Alexandru
Toader, Zaharie
Mihu, Carmen Mihaela
Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology
title Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology
title_full Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology
title_fullStr Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology
title_full_unstemmed Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology
title_short Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology
title_sort hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112759/
https://www.ncbi.nlm.nih.gov/pubmed/33817704
http://dx.doi.org/10.47162/RJME.61.3.01
work_keys_str_mv AT sufletelradateodora hepaticstellatecellsfrompasttillpresentmorphologyhumanmarkershumancelllinesbehaviorinnormalandliverpathology
AT melincovicicarmenstanca hepaticstellatecellsfrompasttillpresentmorphologyhumanmarkershumancelllinesbehaviorinnormalandliverpathology
AT ghebanbogdanalexandru hepaticstellatecellsfrompasttillpresentmorphologyhumanmarkershumancelllinesbehaviorinnormalandliverpathology
AT toaderzaharie hepaticstellatecellsfrompasttillpresentmorphologyhumanmarkershumancelllinesbehaviorinnormalandliverpathology
AT mihucarmenmihaela hepaticstellatecellsfrompasttillpresentmorphologyhumanmarkershumancelllinesbehaviorinnormalandliverpathology

Ejemplares similares