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Medullary thyroid cancer: molecular factors, management and treatment
Medullary thyroid cancer (MTC) is an infrequent neuroendocrine tumor, which amounts to 3–5% of all thyroid malignancies. Approximately 75–80% of MTCs are sporadic neoplasms. The rest of 20–25% are familial cases that belong to multiple endocrine neoplasia (MEN) syndromes, specifically MEN2 and MEN3....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112777/ https://www.ncbi.nlm.nih.gov/pubmed/33817709 http://dx.doi.org/10.47162/RJME.61.3.06 |
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author | Pavlidis, Efstathios Sapalidis, Konstantinos Chatzinikolaou, Fotios Kesisoglou, Isaak |
author_facet | Pavlidis, Efstathios Sapalidis, Konstantinos Chatzinikolaou, Fotios Kesisoglou, Isaak |
author_sort | Pavlidis, Efstathios |
collection | PubMed |
description | Medullary thyroid cancer (MTC) is an infrequent neuroendocrine tumor, which amounts to 3–5% of all thyroid malignancies. Approximately 75–80% of MTCs are sporadic neoplasms. The rest of 20–25% are familial cases that belong to multiple endocrine neoplasia (MEN) syndromes, specifically MEN2 and MEN3. These cases of familial MTC are attributed to an activating germline mutation of a tyrosine kinase receptor gene, the rearranged during transfection (RET) proto-oncogene, located on chromosome 10q11.21. These mutations are also found in some cases of sporadic MTC. This review sets forth in summary the accepted guidelines and approaches regarding diagnosis, management, and treatment of MTC. Surgical resection is the standard care, and an early, prophylactic intervention is performed in genetic cases. Further investigation and understanding of the molecular pathways involved in the growth and advancement of MTC is required in order to provide efficient therapy in cases of progressive disease. |
format | Online Article Text |
id | pubmed-8112777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest |
record_format | MEDLINE/PubMed |
spelling | pubmed-81127772021-06-01 Medullary thyroid cancer: molecular factors, management and treatment Pavlidis, Efstathios Sapalidis, Konstantinos Chatzinikolaou, Fotios Kesisoglou, Isaak Rom J Morphol Embryol Review Medullary thyroid cancer (MTC) is an infrequent neuroendocrine tumor, which amounts to 3–5% of all thyroid malignancies. Approximately 75–80% of MTCs are sporadic neoplasms. The rest of 20–25% are familial cases that belong to multiple endocrine neoplasia (MEN) syndromes, specifically MEN2 and MEN3. These cases of familial MTC are attributed to an activating germline mutation of a tyrosine kinase receptor gene, the rearranged during transfection (RET) proto-oncogene, located on chromosome 10q11.21. These mutations are also found in some cases of sporadic MTC. This review sets forth in summary the accepted guidelines and approaches regarding diagnosis, management, and treatment of MTC. Surgical resection is the standard care, and an early, prophylactic intervention is performed in genetic cases. Further investigation and understanding of the molecular pathways involved in the growth and advancement of MTC is required in order to provide efficient therapy in cases of progressive disease. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2021-03-14 /pmc/articles/PMC8112777/ /pubmed/33817709 http://dx.doi.org/10.47162/RJME.61.3.06 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. |
spellingShingle | Review Pavlidis, Efstathios Sapalidis, Konstantinos Chatzinikolaou, Fotios Kesisoglou, Isaak Medullary thyroid cancer: molecular factors, management and treatment |
title | Medullary thyroid cancer: molecular factors, management and treatment |
title_full | Medullary thyroid cancer: molecular factors, management and treatment |
title_fullStr | Medullary thyroid cancer: molecular factors, management and treatment |
title_full_unstemmed | Medullary thyroid cancer: molecular factors, management and treatment |
title_short | Medullary thyroid cancer: molecular factors, management and treatment |
title_sort | medullary thyroid cancer: molecular factors, management and treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112777/ https://www.ncbi.nlm.nih.gov/pubmed/33817709 http://dx.doi.org/10.47162/RJME.61.3.06 |
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