Cargando…

Phenotypic heterogeneity of non-syndromic supernumerary teeth: genetic study

Background: Numerical dental anomalies, through their phenotypic diversity and etiological complexity, represent a very topical chapter in dental practice. In Romania, there is no recent complex genetic study, regarding supernumerary teeth (ST), as a whole. Patients, Materials and Methods: In this r...

Descripción completa

Detalles Bibliográficos
Autores principales: Albu, Ştefan-Dimitrie, Pavlovici, Romina-Christiana, Imre, Marina, Ion, George, Ţâncu, Ana Maria Cristina, Albu, Cristina-Crenguţa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112786/
https://www.ncbi.nlm.nih.gov/pubmed/33817726
http://dx.doi.org/10.47162/RJME.61.3.23
_version_ 1783690736784375808
author Albu, Ştefan-Dimitrie
Pavlovici, Romina-Christiana
Imre, Marina
Ion, George
Ţâncu, Ana Maria Cristina
Albu, Cristina-Crenguţa
author_facet Albu, Ştefan-Dimitrie
Pavlovici, Romina-Christiana
Imre, Marina
Ion, George
Ţâncu, Ana Maria Cristina
Albu, Cristina-Crenguţa
author_sort Albu, Ştefan-Dimitrie
collection PubMed
description Background: Numerical dental anomalies, through their phenotypic diversity and etiological complexity, represent a very topical chapter in dental practice. In Romania, there is no recent complex genetic study, regarding supernumerary teeth (ST), as a whole. Patients, Materials and Methods: In this research, through the specific genetic study of the phenotypic variability of ST, completed with clinical examinations and paraclinical investigations, to which statistical determinations were added, we performed a complex genetic-clinical and statistical analysis of ST, within a representative group, consisting of 574 patients, who came for specialized dental treatment, between 01/01/2018–05/30/2019, at the private dental offices (Lucky Dental), in Bucharest, Romania. Results: Following this study, it was possible to characterize the phenotypic variability of ST, to analyze the pattern of abnormality genetic transmission in the families of investigated patients, to identify people at risk, and specify the therapeutic conduct of choice, specific to each case. Conclusions: We consider this paper to be of interest for medical practice by bringing new, recent data on the current prevalence of non-syndromic ST, their clinical phenotypes, and the specifics of their genetic determinism in the studied population group.
format Online
Article
Text
id pubmed-8112786
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest
record_format MEDLINE/PubMed
spelling pubmed-81127862021-06-01 Phenotypic heterogeneity of non-syndromic supernumerary teeth: genetic study Albu, Ştefan-Dimitrie Pavlovici, Romina-Christiana Imre, Marina Ion, George Ţâncu, Ana Maria Cristina Albu, Cristina-Crenguţa Rom J Morphol Embryol Original Paper Background: Numerical dental anomalies, through their phenotypic diversity and etiological complexity, represent a very topical chapter in dental practice. In Romania, there is no recent complex genetic study, regarding supernumerary teeth (ST), as a whole. Patients, Materials and Methods: In this research, through the specific genetic study of the phenotypic variability of ST, completed with clinical examinations and paraclinical investigations, to which statistical determinations were added, we performed a complex genetic-clinical and statistical analysis of ST, within a representative group, consisting of 574 patients, who came for specialized dental treatment, between 01/01/2018–05/30/2019, at the private dental offices (Lucky Dental), in Bucharest, Romania. Results: Following this study, it was possible to characterize the phenotypic variability of ST, to analyze the pattern of abnormality genetic transmission in the families of investigated patients, to identify people at risk, and specify the therapeutic conduct of choice, specific to each case. Conclusions: We consider this paper to be of interest for medical practice by bringing new, recent data on the current prevalence of non-syndromic ST, their clinical phenotypes, and the specifics of their genetic determinism in the studied population group. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2021-03-31 /pmc/articles/PMC8112786/ /pubmed/33817726 http://dx.doi.org/10.47162/RJME.61.3.23 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
Albu, Ştefan-Dimitrie
Pavlovici, Romina-Christiana
Imre, Marina
Ion, George
Ţâncu, Ana Maria Cristina
Albu, Cristina-Crenguţa
Phenotypic heterogeneity of non-syndromic supernumerary teeth: genetic study
title Phenotypic heterogeneity of non-syndromic supernumerary teeth: genetic study
title_full Phenotypic heterogeneity of non-syndromic supernumerary teeth: genetic study
title_fullStr Phenotypic heterogeneity of non-syndromic supernumerary teeth: genetic study
title_full_unstemmed Phenotypic heterogeneity of non-syndromic supernumerary teeth: genetic study
title_short Phenotypic heterogeneity of non-syndromic supernumerary teeth: genetic study
title_sort phenotypic heterogeneity of non-syndromic supernumerary teeth: genetic study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112786/
https://www.ncbi.nlm.nih.gov/pubmed/33817726
http://dx.doi.org/10.47162/RJME.61.3.23
work_keys_str_mv AT albustefandimitrie phenotypicheterogeneityofnonsyndromicsupernumeraryteethgeneticstudy
AT pavlovicirominachristiana phenotypicheterogeneityofnonsyndromicsupernumeraryteethgeneticstudy
AT imremarina phenotypicheterogeneityofnonsyndromicsupernumeraryteethgeneticstudy
AT iongeorge phenotypicheterogeneityofnonsyndromicsupernumeraryteethgeneticstudy
AT tancuanamariacristina phenotypicheterogeneityofnonsyndromicsupernumeraryteethgeneticstudy
AT albucristinacrenguta phenotypicheterogeneityofnonsyndromicsupernumeraryteethgeneticstudy