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The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas
Adenoid cystic carcinoma (ACC) is the second most common malignant salivary glands neoplasms with a controversial biological behavior. Even though these tumors grow slowly, they have increased potential for recurrence and distant metastasis. In order to elucidate this behavior, our study aimed to in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112789/ https://www.ncbi.nlm.nih.gov/pubmed/33817718 http://dx.doi.org/10.47162/RJME.61.3.15 |
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author | Belulescu, Iulia Cristiana Mărgăritescu, Claudiu Dumitrescu, Cristiana Iulia Munteanu, Maria Cristina Dăguci, Luminiţa Mărgăritescu, Otilia Clara Matei, Marius |
author_facet | Belulescu, Iulia Cristiana Mărgăritescu, Claudiu Dumitrescu, Cristiana Iulia Munteanu, Maria Cristina Dăguci, Luminiţa Mărgăritescu, Otilia Clara Matei, Marius |
author_sort | Belulescu, Iulia Cristiana |
collection | PubMed |
description | Adenoid cystic carcinoma (ACC) is the second most common malignant salivary glands neoplasms with a controversial biological behavior. Even though these tumors grow slowly, they have increased potential for recurrence and distant metastasis. In order to elucidate this behavior, our study aimed to investigate the immunoexpression in such tumors of the most important transcriptional factors [Twist, Snail, Slug, and zinc finger E-box binding homeobox 1 (ZEB1)] involved in the epithelial–mesenchymal transition process. The highest level of expression was recorded for Twist, present in all the investigated cases, followed by the Slug and Snail, while no tumor parenchyma reactivity was noticed for the ZEB1 factor. There were tumor reactivity differences regarding topography, histopathological variant, and nerve and lymph node invasion status. Thus, tumors developed from the intraoral minor salivary glands, with solid pattern, perineural invasion, locally aggressive and with lymph node metastasis were the most reactive. Therefore, these transcription factors could be useful as prognostic biomarkers and efficient therapeutic targets in such salivary malignancies. |
format | Online Article Text |
id | pubmed-8112789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest |
record_format | MEDLINE/PubMed |
spelling | pubmed-81127892021-06-01 The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas Belulescu, Iulia Cristiana Mărgăritescu, Claudiu Dumitrescu, Cristiana Iulia Munteanu, Maria Cristina Dăguci, Luminiţa Mărgăritescu, Otilia Clara Matei, Marius Rom J Morphol Embryol Original Paper Adenoid cystic carcinoma (ACC) is the second most common malignant salivary glands neoplasms with a controversial biological behavior. Even though these tumors grow slowly, they have increased potential for recurrence and distant metastasis. In order to elucidate this behavior, our study aimed to investigate the immunoexpression in such tumors of the most important transcriptional factors [Twist, Snail, Slug, and zinc finger E-box binding homeobox 1 (ZEB1)] involved in the epithelial–mesenchymal transition process. The highest level of expression was recorded for Twist, present in all the investigated cases, followed by the Slug and Snail, while no tumor parenchyma reactivity was noticed for the ZEB1 factor. There were tumor reactivity differences regarding topography, histopathological variant, and nerve and lymph node invasion status. Thus, tumors developed from the intraoral minor salivary glands, with solid pattern, perineural invasion, locally aggressive and with lymph node metastasis were the most reactive. Therefore, these transcription factors could be useful as prognostic biomarkers and efficient therapeutic targets in such salivary malignancies. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2020-12-30 /pmc/articles/PMC8112789/ /pubmed/33817718 http://dx.doi.org/10.47162/RJME.61.3.15 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. |
spellingShingle | Original Paper Belulescu, Iulia Cristiana Mărgăritescu, Claudiu Dumitrescu, Cristiana Iulia Munteanu, Maria Cristina Dăguci, Luminiţa Mărgăritescu, Otilia Clara Matei, Marius The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas |
title | The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas |
title_full | The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas |
title_fullStr | The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas |
title_full_unstemmed | The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas |
title_short | The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas |
title_sort | immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112789/ https://www.ncbi.nlm.nih.gov/pubmed/33817718 http://dx.doi.org/10.47162/RJME.61.3.15 |
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