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The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas

Adenoid cystic carcinoma (ACC) is the second most common malignant salivary glands neoplasms with a controversial biological behavior. Even though these tumors grow slowly, they have increased potential for recurrence and distant metastasis. In order to elucidate this behavior, our study aimed to in...

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Autores principales: Belulescu, Iulia Cristiana, Mărgăritescu, Claudiu, Dumitrescu, Cristiana Iulia, Munteanu, Maria Cristina, Dăguci, Luminiţa, Mărgăritescu, Otilia Clara, Matei, Marius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112789/
https://www.ncbi.nlm.nih.gov/pubmed/33817718
http://dx.doi.org/10.47162/RJME.61.3.15
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author Belulescu, Iulia Cristiana
Mărgăritescu, Claudiu
Dumitrescu, Cristiana Iulia
Munteanu, Maria Cristina
Dăguci, Luminiţa
Mărgăritescu, Otilia Clara
Matei, Marius
author_facet Belulescu, Iulia Cristiana
Mărgăritescu, Claudiu
Dumitrescu, Cristiana Iulia
Munteanu, Maria Cristina
Dăguci, Luminiţa
Mărgăritescu, Otilia Clara
Matei, Marius
author_sort Belulescu, Iulia Cristiana
collection PubMed
description Adenoid cystic carcinoma (ACC) is the second most common malignant salivary glands neoplasms with a controversial biological behavior. Even though these tumors grow slowly, they have increased potential for recurrence and distant metastasis. In order to elucidate this behavior, our study aimed to investigate the immunoexpression in such tumors of the most important transcriptional factors [Twist, Snail, Slug, and zinc finger E-box binding homeobox 1 (ZEB1)] involved in the epithelial–mesenchymal transition process. The highest level of expression was recorded for Twist, present in all the investigated cases, followed by the Slug and Snail, while no tumor parenchyma reactivity was noticed for the ZEB1 factor. There were tumor reactivity differences regarding topography, histopathological variant, and nerve and lymph node invasion status. Thus, tumors developed from the intraoral minor salivary glands, with solid pattern, perineural invasion, locally aggressive and with lymph node metastasis were the most reactive. Therefore, these transcription factors could be useful as prognostic biomarkers and efficient therapeutic targets in such salivary malignancies.
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spelling pubmed-81127892021-06-01 The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas Belulescu, Iulia Cristiana Mărgăritescu, Claudiu Dumitrescu, Cristiana Iulia Munteanu, Maria Cristina Dăguci, Luminiţa Mărgăritescu, Otilia Clara Matei, Marius Rom J Morphol Embryol Original Paper Adenoid cystic carcinoma (ACC) is the second most common malignant salivary glands neoplasms with a controversial biological behavior. Even though these tumors grow slowly, they have increased potential for recurrence and distant metastasis. In order to elucidate this behavior, our study aimed to investigate the immunoexpression in such tumors of the most important transcriptional factors [Twist, Snail, Slug, and zinc finger E-box binding homeobox 1 (ZEB1)] involved in the epithelial–mesenchymal transition process. The highest level of expression was recorded for Twist, present in all the investigated cases, followed by the Slug and Snail, while no tumor parenchyma reactivity was noticed for the ZEB1 factor. There were tumor reactivity differences regarding topography, histopathological variant, and nerve and lymph node invasion status. Thus, tumors developed from the intraoral minor salivary glands, with solid pattern, perineural invasion, locally aggressive and with lymph node metastasis were the most reactive. Therefore, these transcription factors could be useful as prognostic biomarkers and efficient therapeutic targets in such salivary malignancies. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2020-12-30 /pmc/articles/PMC8112789/ /pubmed/33817718 http://dx.doi.org/10.47162/RJME.61.3.15 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
Belulescu, Iulia Cristiana
Mărgăritescu, Claudiu
Dumitrescu, Cristiana Iulia
Munteanu, Maria Cristina
Dăguci, Luminiţa
Mărgăritescu, Otilia Clara
Matei, Marius
The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas
title The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas
title_full The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas
title_fullStr The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas
title_full_unstemmed The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas
title_short The immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas
title_sort immunophenotype of epithelial to mesenchymal transition inducing transcription factors in salivary gland adenoid cystic carcinomas
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112789/
https://www.ncbi.nlm.nih.gov/pubmed/33817718
http://dx.doi.org/10.47162/RJME.61.3.15
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