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Clinical Manifestations of Allergic Bronchopulmonary Aspergillosis without Major Features of Asthma Diagnosed by the New Criteria in Japan

Allergic bronchopulmonary aspergillosis (ABPA) is a severe form of asthma in which structural airway destruction occurs due to a hypersensitivity reaction to fungi. A 25-year-old man without any major features of asthma had lung infiltration with dilatation of the central bronchus, high-attenuation...

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Autores principales: Kurihara, Yuki, Tashiro, Hiroki, Takahashi, Koichiro, Komiya, Natsuko, Sadamatsu, Hironori, Kimura, Shinya, Sueoka-Aragane, Naoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112978/
https://www.ncbi.nlm.nih.gov/pubmed/33162484
http://dx.doi.org/10.2169/internalmedicine.6072-20
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author Kurihara, Yuki
Tashiro, Hiroki
Takahashi, Koichiro
Komiya, Natsuko
Sadamatsu, Hironori
Kimura, Shinya
Sueoka-Aragane, Naoko
author_facet Kurihara, Yuki
Tashiro, Hiroki
Takahashi, Koichiro
Komiya, Natsuko
Sadamatsu, Hironori
Kimura, Shinya
Sueoka-Aragane, Naoko
author_sort Kurihara, Yuki
collection PubMed
description Allergic bronchopulmonary aspergillosis (ABPA) is a severe form of asthma in which structural airway destruction occurs due to a hypersensitivity reaction to fungi. A 25-year-old man without any major features of asthma had lung infiltration with dilatation of the central bronchus, high-attenuation mucus with histological eosinophilic invasion, fungi detected on cultures, and positive Aspergillus-specific immunoglobulin E (IgE) and precipitating antibody of Aspergillus, with a significant elevation of blood eosinophils and slightly increased total IgE. He recovered rapidly with systemic corticosteroid therapy without recurrence over 1-year follow-up and an increased forced expiratory volume in one second, which supported the possibility of ABPA without any major features of asthma.
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spelling pubmed-81129782021-05-18 Clinical Manifestations of Allergic Bronchopulmonary Aspergillosis without Major Features of Asthma Diagnosed by the New Criteria in Japan Kurihara, Yuki Tashiro, Hiroki Takahashi, Koichiro Komiya, Natsuko Sadamatsu, Hironori Kimura, Shinya Sueoka-Aragane, Naoko Intern Med Case Report Allergic bronchopulmonary aspergillosis (ABPA) is a severe form of asthma in which structural airway destruction occurs due to a hypersensitivity reaction to fungi. A 25-year-old man without any major features of asthma had lung infiltration with dilatation of the central bronchus, high-attenuation mucus with histological eosinophilic invasion, fungi detected on cultures, and positive Aspergillus-specific immunoglobulin E (IgE) and precipitating antibody of Aspergillus, with a significant elevation of blood eosinophils and slightly increased total IgE. He recovered rapidly with systemic corticosteroid therapy without recurrence over 1-year follow-up and an increased forced expiratory volume in one second, which supported the possibility of ABPA without any major features of asthma. The Japanese Society of Internal Medicine 2020-11-09 2021-04-15 /pmc/articles/PMC8112978/ /pubmed/33162484 http://dx.doi.org/10.2169/internalmedicine.6072-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kurihara, Yuki
Tashiro, Hiroki
Takahashi, Koichiro
Komiya, Natsuko
Sadamatsu, Hironori
Kimura, Shinya
Sueoka-Aragane, Naoko
Clinical Manifestations of Allergic Bronchopulmonary Aspergillosis without Major Features of Asthma Diagnosed by the New Criteria in Japan
title Clinical Manifestations of Allergic Bronchopulmonary Aspergillosis without Major Features of Asthma Diagnosed by the New Criteria in Japan
title_full Clinical Manifestations of Allergic Bronchopulmonary Aspergillosis without Major Features of Asthma Diagnosed by the New Criteria in Japan
title_fullStr Clinical Manifestations of Allergic Bronchopulmonary Aspergillosis without Major Features of Asthma Diagnosed by the New Criteria in Japan
title_full_unstemmed Clinical Manifestations of Allergic Bronchopulmonary Aspergillosis without Major Features of Asthma Diagnosed by the New Criteria in Japan
title_short Clinical Manifestations of Allergic Bronchopulmonary Aspergillosis without Major Features of Asthma Diagnosed by the New Criteria in Japan
title_sort clinical manifestations of allergic bronchopulmonary aspergillosis without major features of asthma diagnosed by the new criteria in japan
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112978/
https://www.ncbi.nlm.nih.gov/pubmed/33162484
http://dx.doi.org/10.2169/internalmedicine.6072-20
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