IgA Nephropathy with Dominant IgA2 Deposition Accompanied by Mantle Cell Lymphoma

Malignant lymphoma is rarely complicated by secondary IgA nephropathy. We encountered a 74-year-old man with rapidly progressive glomerulonephritis due to IgA nephropathy with predominant deposition of IgA2, instead of IgA1, in the glomerulus that was eventually diagnosed as secondary IgA nephropath...

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Autores principales: Kakeshita, Kota, Koike, Tsutomu, Imamura, Teruhiko, Wada, Akinori, Kobayashi, Shiori, Fujioka, Hayato, Yamazaki, Hidenori, Kinugawa, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112979/
https://www.ncbi.nlm.nih.gov/pubmed/33116018
http://dx.doi.org/10.2169/internalmedicine.6099-20
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author Kakeshita, Kota
Koike, Tsutomu
Imamura, Teruhiko
Wada, Akinori
Kobayashi, Shiori
Fujioka, Hayato
Yamazaki, Hidenori
Kinugawa, Koichiro
author_facet Kakeshita, Kota
Koike, Tsutomu
Imamura, Teruhiko
Wada, Akinori
Kobayashi, Shiori
Fujioka, Hayato
Yamazaki, Hidenori
Kinugawa, Koichiro
author_sort Kakeshita, Kota
collection PubMed
description Malignant lymphoma is rarely complicated by secondary IgA nephropathy. We encountered a 74-year-old man with rapidly progressive glomerulonephritis due to IgA nephropathy with predominant deposition of IgA2, instead of IgA1, in the glomerulus that was eventually diagnosed as secondary IgA nephropathy due to mantle cell lymphoma. Renal impairment was improved by chemotherapy for the mantle cell lymphoma. IgA came from the colonic mucosa that was stimulated by the infiltrated lymphoma cells, instead of the tumor itself. We should consider mantle cell lymphoma as a cause of secondary IgA nephropathy, although its prevalence may not be very high.
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spelling pubmed-81129792021-05-18 IgA Nephropathy with Dominant IgA2 Deposition Accompanied by Mantle Cell Lymphoma Kakeshita, Kota Koike, Tsutomu Imamura, Teruhiko Wada, Akinori Kobayashi, Shiori Fujioka, Hayato Yamazaki, Hidenori Kinugawa, Koichiro Intern Med Case Report Malignant lymphoma is rarely complicated by secondary IgA nephropathy. We encountered a 74-year-old man with rapidly progressive glomerulonephritis due to IgA nephropathy with predominant deposition of IgA2, instead of IgA1, in the glomerulus that was eventually diagnosed as secondary IgA nephropathy due to mantle cell lymphoma. Renal impairment was improved by chemotherapy for the mantle cell lymphoma. IgA came from the colonic mucosa that was stimulated by the infiltrated lymphoma cells, instead of the tumor itself. We should consider mantle cell lymphoma as a cause of secondary IgA nephropathy, although its prevalence may not be very high. The Japanese Society of Internal Medicine 2020-10-28 2021-04-15 /pmc/articles/PMC8112979/ /pubmed/33116018 http://dx.doi.org/10.2169/internalmedicine.6099-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kakeshita, Kota
Koike, Tsutomu
Imamura, Teruhiko
Wada, Akinori
Kobayashi, Shiori
Fujioka, Hayato
Yamazaki, Hidenori
Kinugawa, Koichiro
IgA Nephropathy with Dominant IgA2 Deposition Accompanied by Mantle Cell Lymphoma
title IgA Nephropathy with Dominant IgA2 Deposition Accompanied by Mantle Cell Lymphoma
title_full IgA Nephropathy with Dominant IgA2 Deposition Accompanied by Mantle Cell Lymphoma
title_fullStr IgA Nephropathy with Dominant IgA2 Deposition Accompanied by Mantle Cell Lymphoma
title_full_unstemmed IgA Nephropathy with Dominant IgA2 Deposition Accompanied by Mantle Cell Lymphoma
title_short IgA Nephropathy with Dominant IgA2 Deposition Accompanied by Mantle Cell Lymphoma
title_sort iga nephropathy with dominant iga2 deposition accompanied by mantle cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112979/
https://www.ncbi.nlm.nih.gov/pubmed/33116018
http://dx.doi.org/10.2169/internalmedicine.6099-20
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