Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma

We herein report a case of aortitis induced by granulocyte colony-stimulating factor (G-CSF) that coincided with lung injury, splenomegaly, and cutaneous manifestations during treatment for recurrent extraosseous mucinous chondrosarcoma. Computed tomography revealed large-vessel vasculitis, splenome...

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Detalles Bibliográficos
Autores principales: Kametani, Takahiro, Otani, Yuichiro, Ohigashi, Toshikazu, Kubo, Tadahiko, Sakuda, Tomohiko, Furuta, Daisuke, Ito, Yayoiko, Shigenobu, Yuya, Kakimoto, Masaki, Kawahara, Akihiro, Kikuchi, Yuka, Kobayashi, Tomoki, Miyamori, Daisuke, Kishikawa, Nobusuke, Kanno, Keishi, Ito, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112981/
https://www.ncbi.nlm.nih.gov/pubmed/33191326
http://dx.doi.org/10.2169/internalmedicine.5913-20
Descripción
Sumario:We herein report a case of aortitis induced by granulocyte colony-stimulating factor (G-CSF) that coincided with lung injury, splenomegaly, and cutaneous manifestations during treatment for recurrent extraosseous mucinous chondrosarcoma. Computed tomography revealed large-vessel vasculitis, splenomegaly, and pulmonary interstitial changes. Treatment with prednisolone was successful. Because sarcoma is a rare disease, this case is valuable for showing clinicians that G-CSF preparations could cause aortitis regardless of the patient's underlying diseases or therapeutic pharmacological backgrounds.

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