Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma

We herein report a case of aortitis induced by granulocyte colony-stimulating factor (G-CSF) that coincided with lung injury, splenomegaly, and cutaneous manifestations during treatment for recurrent extraosseous mucinous chondrosarcoma. Computed tomography revealed large-vessel vasculitis, splenome...

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Autores principales: Kametani, Takahiro, Otani, Yuichiro, Ohigashi, Toshikazu, Kubo, Tadahiko, Sakuda, Tomohiko, Furuta, Daisuke, Ito, Yayoiko, Shigenobu, Yuya, Kakimoto, Masaki, Kawahara, Akihiro, Kikuchi, Yuka, Kobayashi, Tomoki, Miyamori, Daisuke, Kishikawa, Nobusuke, Kanno, Keishi, Ito, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112981/
https://www.ncbi.nlm.nih.gov/pubmed/33191326
http://dx.doi.org/10.2169/internalmedicine.5913-20
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author Kametani, Takahiro
Otani, Yuichiro
Ohigashi, Toshikazu
Kubo, Tadahiko
Sakuda, Tomohiko
Furuta, Daisuke
Ito, Yayoiko
Shigenobu, Yuya
Kakimoto, Masaki
Kawahara, Akihiro
Kikuchi, Yuka
Kobayashi, Tomoki
Miyamori, Daisuke
Kishikawa, Nobusuke
Kanno, Keishi
Ito, Masanori
author_facet Kametani, Takahiro
Otani, Yuichiro
Ohigashi, Toshikazu
Kubo, Tadahiko
Sakuda, Tomohiko
Furuta, Daisuke
Ito, Yayoiko
Shigenobu, Yuya
Kakimoto, Masaki
Kawahara, Akihiro
Kikuchi, Yuka
Kobayashi, Tomoki
Miyamori, Daisuke
Kishikawa, Nobusuke
Kanno, Keishi
Ito, Masanori
author_sort Kametani, Takahiro
collection PubMed
description We herein report a case of aortitis induced by granulocyte colony-stimulating factor (G-CSF) that coincided with lung injury, splenomegaly, and cutaneous manifestations during treatment for recurrent extraosseous mucinous chondrosarcoma. Computed tomography revealed large-vessel vasculitis, splenomegaly, and pulmonary interstitial changes. Treatment with prednisolone was successful. Because sarcoma is a rare disease, this case is valuable for showing clinicians that G-CSF preparations could cause aortitis regardless of the patient's underlying diseases or therapeutic pharmacological backgrounds.
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spelling pubmed-81129812021-05-18 Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma Kametani, Takahiro Otani, Yuichiro Ohigashi, Toshikazu Kubo, Tadahiko Sakuda, Tomohiko Furuta, Daisuke Ito, Yayoiko Shigenobu, Yuya Kakimoto, Masaki Kawahara, Akihiro Kikuchi, Yuka Kobayashi, Tomoki Miyamori, Daisuke Kishikawa, Nobusuke Kanno, Keishi Ito, Masanori Intern Med Case Report We herein report a case of aortitis induced by granulocyte colony-stimulating factor (G-CSF) that coincided with lung injury, splenomegaly, and cutaneous manifestations during treatment for recurrent extraosseous mucinous chondrosarcoma. Computed tomography revealed large-vessel vasculitis, splenomegaly, and pulmonary interstitial changes. Treatment with prednisolone was successful. Because sarcoma is a rare disease, this case is valuable for showing clinicians that G-CSF preparations could cause aortitis regardless of the patient's underlying diseases or therapeutic pharmacological backgrounds. The Japanese Society of Internal Medicine 2020-11-16 2021-04-15 /pmc/articles/PMC8112981/ /pubmed/33191326 http://dx.doi.org/10.2169/internalmedicine.5913-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kametani, Takahiro
Otani, Yuichiro
Ohigashi, Toshikazu
Kubo, Tadahiko
Sakuda, Tomohiko
Furuta, Daisuke
Ito, Yayoiko
Shigenobu, Yuya
Kakimoto, Masaki
Kawahara, Akihiro
Kikuchi, Yuka
Kobayashi, Tomoki
Miyamori, Daisuke
Kishikawa, Nobusuke
Kanno, Keishi
Ito, Masanori
Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma
title Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma
title_full Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma
title_fullStr Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma
title_full_unstemmed Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma
title_short Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma
title_sort granulocyte colony-stimulating factor-induced aortitis with lung injury, splenomegaly, and a rash during treatment for recurrent extraosseous mucinous chondrosarcoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112981/
https://www.ncbi.nlm.nih.gov/pubmed/33191326
http://dx.doi.org/10.2169/internalmedicine.5913-20
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