Antiviral drug Triazavirin, selectively labeled with (2)H, (13)C, and (15)N stable isotopes. Synthesis and properties

[Image: see text] Isotope-labeled antiviral drug Triazavirin containing (2)H, (13)C, and (15)N atoms in its structure has been synthesized. (13)C(2)H(3)I and KS(13)CN served as donors of (13)C isotopes. The use of (13)С-MeI containing (2)H atoms made it possible to additionally incorporate deuterium...

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Detalles Bibliográficos
Autores principales: Shestakova, Tatyana S., Deev, Sergey L., Khalymbadzha, Igor А., Rusinov, Vladimir L., Paramonov, Alexander S., Arseniev, Alexander S., Shenkarev, Zakhar O., Charushin, Valery N., Chupakhin, Oleg N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113018/
https://www.ncbi.nlm.nih.gov/pubmed/33994553
http://dx.doi.org/10.1007/s10593-021-02927-1
Descripción
Sumario:[Image: see text] Isotope-labeled antiviral drug Triazavirin containing (2)H, (13)C, and (15)N atoms in its structure has been synthesized. (13)C(2)H(3)I and KS(13)CN served as donors of (13)C isotopes. The use of (13)С-MeI containing (2)H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The (15)N atoms were incorporated using (15)N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting (2)H(3),(13)C(2),(15)N(3)-Triazavirin was characterized by NMR spectroscopy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10593-021-02927-1.

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