Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols

[Image: see text] An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-с][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses. SUPPLEMENTARY INFORMATION: The on...

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Autores principales: Drokin, Roman A., Tiufiakov, Dmitrii V., Voinkov, Egor K., Slepukhin, Pavel A., Ulomsky, Evgeny N., Esaulkova, Yana L., Volobueva, Alexandrina S., Lantseva, Kristina S., Misyurina, Mariya A., Zarubaev, Vladimir V., Rusinov, Vladimir L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113020/
https://www.ncbi.nlm.nih.gov/pubmed/33994554
http://dx.doi.org/10.1007/s10593-021-02926-2
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author Drokin, Roman A.
Tiufiakov, Dmitrii V.
Voinkov, Egor K.
Slepukhin, Pavel A.
Ulomsky, Evgeny N.
Esaulkova, Yana L.
Volobueva, Alexandrina S.
Lantseva, Kristina S.
Misyurina, Mariya A.
Zarubaev, Vladimir V.
Rusinov, Vladimir L.
author_facet Drokin, Roman A.
Tiufiakov, Dmitrii V.
Voinkov, Egor K.
Slepukhin, Pavel A.
Ulomsky, Evgeny N.
Esaulkova, Yana L.
Volobueva, Alexandrina S.
Lantseva, Kristina S.
Misyurina, Mariya A.
Zarubaev, Vladimir V.
Rusinov, Vladimir L.
author_sort Drokin, Roman A.
collection PubMed
description [Image: see text] An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-с][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10593-021-02926-2.
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spelling pubmed-81130202021-05-12 Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols Drokin, Roman A. Tiufiakov, Dmitrii V. Voinkov, Egor K. Slepukhin, Pavel A. Ulomsky, Evgeny N. Esaulkova, Yana L. Volobueva, Alexandrina S. Lantseva, Kristina S. Misyurina, Mariya A. Zarubaev, Vladimir V. Rusinov, Vladimir L. Chem Heterocycl Compd (N Y) Article [Image: see text] An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-с][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10593-021-02926-2. Springer US 2021-05-12 2021 /pmc/articles/PMC8113020/ /pubmed/33994554 http://dx.doi.org/10.1007/s10593-021-02926-2 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Drokin, Roman A.
Tiufiakov, Dmitrii V.
Voinkov, Egor K.
Slepukhin, Pavel A.
Ulomsky, Evgeny N.
Esaulkova, Yana L.
Volobueva, Alexandrina S.
Lantseva, Kristina S.
Misyurina, Mariya A.
Zarubaev, Vladimir V.
Rusinov, Vladimir L.
Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols
title Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols
title_full Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols
title_fullStr Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols
title_full_unstemmed Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols
title_short Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols
title_sort methods of synthesis and antiviral activity of new 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-c][1,2,4]triazin-4-ols
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113020/
https://www.ncbi.nlm.nih.gov/pubmed/33994554
http://dx.doi.org/10.1007/s10593-021-02926-2
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