The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes

The soluble receptor for advanced glycation end-products (sRAGE) has been classically considered a sink for pro-inflammatory RAGE ligands and as such has been associated with protection from inflammatory stress and disease. An alternative, though not mutually exclusive view is that high levels of sR...

Descripción completa

Detalles Bibliográficos
Autor principal: Erusalimsky, Jorge D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Articles from the Special Issue on Oxidative stress in retina and retinal pigment epithelium in health and disease; Edited by Dr. Vera Bonilha
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113049/
https://www.ncbi.nlm.nih.gov/pubmed/33839083
http://dx.doi.org/10.1016/j.redox.2021.101958
_version_ 1783690794463395840
author Erusalimsky, Jorge D.
author_facet Erusalimsky, Jorge D.
author_sort Erusalimsky, Jorge D.
collection PubMed
description The soluble receptor for advanced glycation end-products (sRAGE) has been classically considered a sink for pro-inflammatory RAGE ligands and as such has been associated with protection from inflammatory stress and disease. An alternative, though not mutually exclusive view is that high levels of sRAGE in circulation reflect the overstimulation of cell surface RAGE which if persistent, lead to the amplification of pro-inflammatory processes and the exacerbation of pathological states. With these two scenarios in mind this review focuses on the potential role of sRAGE as a prospective biomarker of disease risk and adverse outcomes.
format Online
Article
Text
id pubmed-8113049
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-81130492021-05-18 The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes Erusalimsky, Jorge D. Redox Biol Articles from the Special Issue on Oxidative stress in retina and retinal pigment epithelium in health and disease; Edited by Dr. Vera Bonilha The soluble receptor for advanced glycation end-products (sRAGE) has been classically considered a sink for pro-inflammatory RAGE ligands and as such has been associated with protection from inflammatory stress and disease. An alternative, though not mutually exclusive view is that high levels of sRAGE in circulation reflect the overstimulation of cell surface RAGE which if persistent, lead to the amplification of pro-inflammatory processes and the exacerbation of pathological states. With these two scenarios in mind this review focuses on the potential role of sRAGE as a prospective biomarker of disease risk and adverse outcomes. Elsevier 2021-03-29 /pmc/articles/PMC8113049/ /pubmed/33839083 http://dx.doi.org/10.1016/j.redox.2021.101958 Text en © 2021 The Author https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Articles from the Special Issue on Oxidative stress in retina and retinal pigment epithelium in health and disease; Edited by Dr. Vera Bonilha
Erusalimsky, Jorge D.
The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes
title The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes
title_full The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes
title_fullStr The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes
title_full_unstemmed The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes
title_short The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes
title_sort use of the soluble receptor for advanced glycation-end products (srage) as a potential biomarker of disease risk and adverse outcomes
topic Articles from the Special Issue on Oxidative stress in retina and retinal pigment epithelium in health and disease; Edited by Dr. Vera Bonilha
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113049/
https://www.ncbi.nlm.nih.gov/pubmed/33839083
http://dx.doi.org/10.1016/j.redox.2021.101958
work_keys_str_mv AT erusalimskyjorged theuseofthesolublereceptorforadvancedglycationendproductssrageasapotentialbiomarkerofdiseaseriskandadverseoutcomes
AT erusalimskyjorged useofthesolublereceptorforadvancedglycationendproductssrageasapotentialbiomarkerofdiseaseriskandadverseoutcomes

Ejemplares similares