Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature

Myasthenia gravis (MG) is an autoimmune disease characterized by impaired neuromuscular signaling due to autoantibodies targeting the acetylcholine receptor. Although its auto-antigens and effector mechanisms are well defined, the cellular and molecular drivers underpinning MG remain elusive. Here,...

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Detalles Bibliográficos
Autores principales: Ingelfinger, Florian, Krishnarajah, Sinduya, Kramer, Michael, Utz, Sebastian G., Galli, Edoardo, Lutz, Mirjam, Zwicky, Pascale, Akarca, Ayse U., Jurado, Nicole Puertas, Ulutekin, Can, Bamert, David, Widmer, Corinne C., Piccoli, Luca, Sallusto, Federica, Núñez, Nicolás G., Marafioti, Teresa, Schneiter, Didier, Opitz, Isabelle, Lanzavecchia, Antonio, Jung, Hans H., De Feo, Donatella, Mundt, Sarah, Schreiner, Bettina, Becher, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113175/
https://www.ncbi.nlm.nih.gov/pubmed/33774709
http://dx.doi.org/10.1007/s00401-021-02299-y

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