Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer’s disease (AD) mouse model and is increased at early stage in sporadic AD brain

One of the main components of senile plaques in Alzheimer’s disease (AD)-affected brain is the Aβ peptide species harboring a pyroglutamate at position three pE3-Aβ. Several studies indicated that pE3-Aβ is toxic, prone to aggregation and serves as a seed of Aβ aggregation. The cyclisation of the gl...

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Detalles Bibliográficos
Autores principales: Valverde, Audrey, Dunys, Julie, Lorivel, Thomas, Debayle, Delphine, Gay, Anne-Sophie, Lacas-Gervais, Sandra, Roques, Bernard. P., Chami, Mounia, Checler, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113186/
https://www.ncbi.nlm.nih.gov/pubmed/33881611
http://dx.doi.org/10.1007/s00401-021-02308-0

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