Cargando…

Effect of cryopreservation on DNA damage and DNA repair activity in human blood samples in the comet assay

The comet assay is a commonly used method to determine DNA damage and repair activity in many types of samples. In recent years, the use of the comet assay in human biomonitoring became highly attractive due to its various modified versions, which may be useful to determine individual susceptibility...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bankoglu, Ezgi Eyluel, Stipp, Franzisca, Gerber, Johanna, Seyfried, Florian, Heidland, August, Bahner, Udo, Stopper, Helga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Genotoxicity and Carcinogenicity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113209/ https://www.ncbi.nlm.nih.gov/pubmed/33666708 http://dx.doi.org/10.1007/s00204-021-03012-4

Ejemplares similares

Cell survival after DNA damage in the comet assay
por: Bankoglu, Ezgi Eyluel, et al.
Publicado: (2021)

Genotoxicity of pyrrolizidine alkaloids in metabolically inactive human cervical cancer HeLa cells co-cultured with human hepatoma HepG2 cells
por: Hadi, Naji Said Aboud, et al.
Publicado: (2022)

Validation of the in vitro comet assay for DNA cross-links and altered bases detection
por: Muruzabal, Damián, et al.
Publicado: (2021)

Salivary leucocytes as suitable biomatrix for the comet assay in human biomonitoring studies
por: Fernández-Bertólez, Natalia, et al.
Publicado: (2021)

Long-term fate of etoposide-induced micronuclei and micronucleated cells in Hela-H2B-GFP cells
por: Reimann, Hauke, et al.
Publicado: (2020)

Fate of micronuclei and micronucleated cells after treatment of HeLa cells with different genotoxic agents
por: Reimann, Hauke, et al.
Publicado: (2022)

Comparison of comet-based approaches to assess base excision repair
por: Zheng, Congying, et al.
Publicado: (2023)

Feeding Brassica vegetables to rats leads to the formation of characteristic DNA adducts (from 1-methoxy-3-indolylmethyl glucosinolate) in many tissues
por: Glatt, Hansruedi, et al.
Publicado: (2022)

BPDE-induced genotoxicity: relationship between DNA adducts, mutagenicity in the in vitro PIG-A assay, and the transcriptional response to DNA damage in TK6 cells
por: Piberger, Ann Liza, et al.
Publicado: (2017)

Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix
por: Yang, Shuo, et al.
Publicado: (2020)

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone
por: Arlt, Volker M., et al.
Publicado: (2016)

Acidic cellular microenvironment modifies carcinogen-induced DNA damage and repair
por: Shi, Q., et al.
Publicado: (2016)

Bisphenol A-glycidyl methacrylate induces a broad spectrum of DNA damage in human lymphocytes
por: Drozdz, Kinga, et al.
Publicado: (2010)

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro
por: Sborchia, Mateja, et al.
Publicado: (2019)

Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells
por: Müller, Lena, et al.
Publicado: (2021)

Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells
por: Russo, Chiara, et al.
Publicado: (2018)

The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines
por: Kolbinger, Fiona R., et al.
Publicado: (2018)

Influence of breast cancer risk factors on proliferation and DNA damage in human breast glandular tissues: role of intracellular estrogen levels, oxidative stress and estrogen biotransformation
por: Wunder, Juliane, et al.
Publicado: (2021)

Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning
por: Wills, John W., et al.
Publicado: (2021)

Cytochrome b(5) impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b(5)/P450 reductase null (HBRN) mice
por: Reed, Lindsay, et al.
Publicado: (2018)

Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances
por: Lim, Hui Kheng, et al.
Publicado: (2022)

The benzene metabolite para-benzoquinone is genotoxic in human, phorbol-12-acetate-13-myristate induced, peripheral blood mononuclear cells at low concentrations
por: Westphal, Götz Alexander, et al.
Publicado: (2009)

Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene
por: Shi, Q., et al.
Publicado: (2015)

Genotoxic properties of XLR-11, a widely consumed synthetic cannabinoid, and of the benzoyl indole RCS-4
por: Ferk, Franziska, et al.
Publicado: (2016)

Ethanol potentiates the genotoxicity of the food-derived mammary carcinogen PhIP in human estrogen receptor-positive mammary cells: mechanistic support for lifestyle factors (cooked red meat and ethanol) associated with mammary cancer
por: Malik, Durr-e-shahwar, et al.
Publicado: (2018)

PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity
por: Fischer, Jan M. F., et al.
Publicado: (2017)

Environmentally prevalent polycyclic aromatic hydrocarbons can elicit co-carcinogenic properties in an in vitro murine lung epithelial cell model
por: Bauer, Alison K., et al.
Publicado: (2017)

Mesenchyme-derived factors enhance preneoplastic growth by non-genotoxic carcinogens in rat liver
por: Nejabat, Marzieh, et al.
Publicado: (2017)

A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells
por: Wilde, Eleanor C., et al.
Publicado: (2017)

Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?
por: Waldherr, Monika, et al.
Publicado: (2017)

Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene
por: Long, Alexandra S., et al.
Publicado: (2017)

Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human
por: Pognan, Francois, et al.
Publicado: (2018)

Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells
por: Malik, Durr-e-shahwar, et al.
Publicado: (2018)

Synthesis and in vitro characterization of the genotoxic, mutagenic and cell-transforming potential of nitrosylated heme
por: Kostka, Tina, et al.
Publicado: (2020)

Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) induce epigenetic alterations and promote human breast cell carcinogenesis in vitro
por: Pierozan, Paula, et al.
Publicado: (2020)

Following the adverse outcome pathway from micronucleus to cancer using H2B-eGFP transgenic healthy stem cells
por: Hölzel, Bastian Niklas, et al.
Publicado: (2020)

Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro
por: Crudo, Francesco, et al.
Publicado: (2020)

Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts
por: Hölzl-Armstrong, Lisa, et al.
Publicado: (2020)

Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells
por: Rutz, Lukas, et al.
Publicado: (2020)

Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway
por: Abbass, Mustafa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mu8gjtvrq9es3h6und0e2m0vh7