A unified resource and configurable model of the synapse proteome and its role in disease

Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein–protein interactions and functional metadata to build...

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Detalles Bibliográficos
Autores principales: Sorokina, Oksana, Mclean, Colin, Croning, Mike D. R., Heil, Katharina F., Wysocka, Emilia, He, Xin, Sterratt, David, Grant, Seth G. N., Simpson, T. Ian, Armstrong, J. Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113277/
https://www.ncbi.nlm.nih.gov/pubmed/33976238
http://dx.doi.org/10.1038/s41598-021-88945-7
Descripción
Sumario:Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein–protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.

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