A unified resource and configurable model of the synapse proteome and its role in disease

Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein–protein interactions and functional metadata to build...

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Autores principales: Sorokina, Oksana, Mclean, Colin, Croning, Mike D. R., Heil, Katharina F., Wysocka, Emilia, He, Xin, Sterratt, David, Grant, Seth G. N., Simpson, T. Ian, Armstrong, J. Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113277/
https://www.ncbi.nlm.nih.gov/pubmed/33976238
http://dx.doi.org/10.1038/s41598-021-88945-7
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author Sorokina, Oksana
Mclean, Colin
Croning, Mike D. R.
Heil, Katharina F.
Wysocka, Emilia
He, Xin
Sterratt, David
Grant, Seth G. N.
Simpson, T. Ian
Armstrong, J. Douglas
author_facet Sorokina, Oksana
Mclean, Colin
Croning, Mike D. R.
Heil, Katharina F.
Wysocka, Emilia
He, Xin
Sterratt, David
Grant, Seth G. N.
Simpson, T. Ian
Armstrong, J. Douglas
author_sort Sorokina, Oksana
collection PubMed
description Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein–protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.
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spelling pubmed-81132772021-05-12 A unified resource and configurable model of the synapse proteome and its role in disease Sorokina, Oksana Mclean, Colin Croning, Mike D. R. Heil, Katharina F. Wysocka, Emilia He, Xin Sterratt, David Grant, Seth G. N. Simpson, T. Ian Armstrong, J. Douglas Sci Rep Article Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein–protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use. Nature Publishing Group UK 2021-05-11 /pmc/articles/PMC8113277/ /pubmed/33976238 http://dx.doi.org/10.1038/s41598-021-88945-7 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sorokina, Oksana
Mclean, Colin
Croning, Mike D. R.
Heil, Katharina F.
Wysocka, Emilia
He, Xin
Sterratt, David
Grant, Seth G. N.
Simpson, T. Ian
Armstrong, J. Douglas
A unified resource and configurable model of the synapse proteome and its role in disease
title A unified resource and configurable model of the synapse proteome and its role in disease
title_full A unified resource and configurable model of the synapse proteome and its role in disease
title_fullStr A unified resource and configurable model of the synapse proteome and its role in disease
title_full_unstemmed A unified resource and configurable model of the synapse proteome and its role in disease
title_short A unified resource and configurable model of the synapse proteome and its role in disease
title_sort unified resource and configurable model of the synapse proteome and its role in disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113277/
https://www.ncbi.nlm.nih.gov/pubmed/33976238
http://dx.doi.org/10.1038/s41598-021-88945-7
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