Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae

Multidrug and toxic compound extrusion (MATE) transport proteins confer multidrug resistance on pathogenic microorganisms and affect pharmacokinetics in mammals. Our understanding of how MATE transporters work, has mostly relied on protein structures and MD simulations. However, the energetics of dr...

Descripción completa

Detalles Bibliográficos
Autores principales: Raturi, Sagar, Nair, Asha V., Shinoda, Keiko, Singh, Himansha, Bai, Boyan, Murakami, Satoshi, Fujitani, Hideaki, van Veen, Hendrik W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113278/
https://www.ncbi.nlm.nih.gov/pubmed/33976372
http://dx.doi.org/10.1038/s42003-021-02081-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113278/
https://www.ncbi.nlm.nih.gov/pubmed/33976372
http://dx.doi.org/10.1038/s42003-021-02081-6

Ejemplares similares