Cargando…

A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca(2+)-signalling

Methods to assess neuronal receptor functions are needed in toxicology and for drug development. Human-based test systems that allow studies on glutamate signalling are still scarce. To address this issue, we developed and characterized pluripotent stem cell (PSC)-based neural cultures capable of fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klima, Stefanie, Brüll, Markus, Spreng, Anna-Sophie, Suciu, Ilinca, Falt, Tjalda, Schwamborn, Jens C., Waldmann, Tanja, Karreman, Christiaan, Leist, Marcel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	In Vitro Systems
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113295/ https://www.ncbi.nlm.nih.gov/pubmed/33713149 http://dx.doi.org/10.1007/s00204-021-03024-0

Ejemplares similares

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons
por: Loser, Dominik, et al.
Publicado: (2021)

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta
por: Pallocca, Giorgia, et al.
Publicado: (2017)

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration
por: Pallocca, Giorgia, et al.
Publicado: (2015)

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift
por: Gutbier, Simon, et al.
Publicado: (2018)

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors
por: Delp, Johannes, et al.
Publicado: (2021)

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis
por: Smirnova, L., et al.
Publicado: (2015)

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors
por: Rempel, Eugen, et al.
Publicado: (2015)

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation
por: Spreng, Anna-Sophie, et al.
Publicado: (2022)

Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery
por: Zimmer, B., et al.
Publicado: (2014)

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox(ukn) and STOP-Tox(ukk) tests
por: Shinde, Vaibhav, et al.
Publicado: (2016)

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress
por: Gutbier, Simon, et al.
Publicado: (2018)

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro
por: Holzer, Anna-Katharina, et al.
Publicado: (2022)

A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles
por: Hoelting, Lisa, et al.
Publicado: (2012)

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay
por: Colaianna, Marilena, et al.
Publicado: (2016)

Comparing in vitro human liver models to in vivo human liver using RNA-Seq
por: Gupta, Rajinder, et al.
Publicado: (2020)

Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants
por: Hirsch, Cordula, et al.
Publicado: (2016)

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone
por: Harris, Georgina, et al.
Publicado: (2018)

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models
por: Capinha, Liliana, et al.
Publicado: (2022)

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods
por: Krebs, Alice, et al.
Publicado: (2020)

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
por: van der Stel, Wanda, et al.
Publicado: (2021)

Cytotoxicity, metabolism, and isozyme mapping of the synthetic cannabinoids JWH-200, A-796260, and 5F-EMB-PINACA studied by means of in vitro systems
por: Gampfer, Tanja M., et al.
Publicado: (2021)

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons
por: Suciu, Ilinca, et al.
Publicado: (2023)

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
por: Proctor, William R., et al.
Publicado: (2017)

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue
por: Godoy, Patricio, et al.
Publicado: (2016)

Human neuronal signaling and communication assays to assess functional neurotoxicity
por: Loser, Dominik, et al.
Publicado: (2020)

Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods
por: Adriaens, Els, et al.
Publicado: (2013)

Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium
por: Fischer, Bettina Maria, et al.
Publicado: (2015)

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment
por: Chaudhari, Umesh, et al.
Publicado: (2015)

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells
por: Nemade, Harshal, et al.
Publicado: (2018)

Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity
por: Reffatto, V., et al.
Publicado: (2017)

Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells
por: Lucendo-Villarin, Baltasar, et al.
Publicado: (2017)

Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis
por: Piao, Mei Jing, et al.
Publicado: (2018)

Building predictive in vitro pulmonary toxicity assays using high-throughput imaging and artificial intelligence
por: Lee, Jia-Ying Joey, et al.
Publicado: (2018)

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury
por: Wink, Steven, et al.
Publicado: (2018)

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2017)

Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds
por: Karhu, S. Tuuli, et al.
Publicado: (2018)

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo
por: Rashidi, Hassan, et al.
Publicado: (2018)

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury
por: Copple, Ian M., et al.
Publicado: (2018)

Identification of anticancer OATP2B1 substrates by an in vitro triple-fluorescence-based cytotoxicity screen
por: Windt, Tímea, et al.
Publicado: (2019)

Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients
por: Thiel, Christoph, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_30fchjcb53jlo6hq1dpkj4pod1