Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice

Allergic asthma is characterized by elevated levels of IgE antibodies, type 2 cytokines such as interleukin-4 (IL-4) and IL-13, airway hyperresponsiveness (AHR), mucus hypersecretion and eosinophilia. Approved therapeutic monoclonal antibodies targeting IgE or IL-4/IL-13 reduce asthma symptoms but r...

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Detalles Bibliográficos
Autores principales: Conde, Eva, Bertrand, Romain, Balbino, Bianca, Bonnefoy, Jonathan, Stackowicz, Julien, Caillot, Noémie, Colaone, Fabien, Hamdi, Samir, Houmadi, Raïssa, Loste, Alexia, Kamphuis, Jasper B. J., Huetz, François, Guilleminault, Laurent, Gaudenzio, Nicolas, Mougel, Aurélie, Hardy, David, Snouwaert, John N., Koller, Beverly H., Serra, Vincent, Bruhns, Pierre, Grouard-Vogel, Géraldine, Reber, Laurent L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113315/
https://www.ncbi.nlm.nih.gov/pubmed/33976140
http://dx.doi.org/10.1038/s41467-021-22834-5

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