Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture of invasive lung ADC and its precursors by transcriptomic immune profiling, T cell receptor (TCR) sequencing and multiplex immunofluor...

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Detalles Bibliográficos
Autores principales: Dejima, Hitoshi, Hu, Xin, Chen, Runzhe, Zhang, Jiexin, Fujimoto, Junya, Parra, Edwin R., Haymaker, Cara, Hubert, Shawna M., Duose, Dzifa, Solis, Luisa M., Su, Dan, Fukuoka, Junya, Tabata, Kazuhiro, Pham, Hoa H. N., Mcgranahan, Nicholas, Zhang, Baili, Ye, Jie, Ying, Lisha, Little, Latasha, Gumbs, Curtis, Chow, Chi-Wan, Estecio, Marcos Roberto, Godoy, Myrna C. B., Antonoff, Mara B., Sepesi, Boris, Pass, Harvey I., Behrens, Carmen, Zhang, Jianhua, Vaporciyan, Ara A., Heymach, John V., Scheet, Paul, Lee, J. Jack, Wu, Jia, Futreal, P. Andrew, Reuben, Alexandre, Kadara, Humam, Wistuba, Ignacio I., Zhang, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113327/
https://www.ncbi.nlm.nih.gov/pubmed/33976164
http://dx.doi.org/10.1038/s41467-021-22890-x

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