Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO

Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until dissection or rupture, requiring surgical intervention as the only available treatment. Here, we show that nitric oxide (NO) signaling dysregulates actin cytoskeleton dynamics in Marfan Syndrome smooth muscle cel...

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Detalles Bibliográficos
Autores principales: de la Fuente-Alonso, Andrea, Toral, Marta, Alfayate, Alvaro, Ruiz-Rodríguez, María Jesús, Bonzón-Kulichenko, Elena, Teixido-Tura, Gisela, Martínez-Martínez, Sara, Méndez-Olivares, María José, López-Maderuelo, Dolores, González-Valdés, Ileana, Garcia-Izquierdo, Eusebio, Mingo, Susana, Martín, Carlos E., Muiño-Mosquera, Laura, De Backer, Julie, Nistal, J. Francisco, Forteza, Alberto, Evangelista, Arturo, Vázquez, Jesús, Campanero, Miguel R., Redondo, Juan Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113458/
https://www.ncbi.nlm.nih.gov/pubmed/33976159
http://dx.doi.org/10.1038/s41467-021-22933-3

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