Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons

mTOR signaling, involving mTORC1 and mTORC2 complexes, critically regulates neural development and is implicated in various brain disorders. However, we do not fully understand all of the upstream signaling components that can regulate mTOR signaling, especially in neurons. Here, we show a direct, r...

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Detalles Bibliográficos
Autores principales: Kim, Sun-Gyun, Lee, Suho, Kim, Yangsik, Park, Jieun, Woo, Doyeon, Kim, Dayeon, Li, Yan, Shin, Wangyong, Kang, Hyunjeong, Yook, Chaehyun, Lee, Minji, Kim, Kyungdeok, Roh, Junyeop Daniel, Ryu, Jeseung, Jung, Hwajin, Um, Seung Min, Yang, Esther, Kim, Hyun, Han, Jinju, Heo, Won Do, Kim, Eunjoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113471/
https://www.ncbi.nlm.nih.gov/pubmed/33976205
http://dx.doi.org/10.1038/s41467-021-22908-4

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