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Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures

In addition to microgravity, spaceflight simultaneously exposes biology to a suite of other stimuli. For example, in space, organisms experience ionizing radiation environments that significantly differ in both quality and quantity from those normally experienced on Earth. However, data on radiation...

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Autores principales: Barker, Richard, Costes, Sylvain V., Miller, Jack, Gebre, Samrawit G., Lombardino, Jonathan, Gilroy, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113475/
https://www.ncbi.nlm.nih.gov/pubmed/33976230
http://dx.doi.org/10.1038/s41526-021-00143-x
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author Barker, Richard
Costes, Sylvain V.
Miller, Jack
Gebre, Samrawit G.
Lombardino, Jonathan
Gilroy, Simon
author_facet Barker, Richard
Costes, Sylvain V.
Miller, Jack
Gebre, Samrawit G.
Lombardino, Jonathan
Gilroy, Simon
author_sort Barker, Richard
collection PubMed
description In addition to microgravity, spaceflight simultaneously exposes biology to a suite of other stimuli. For example, in space, organisms experience ionizing radiation environments that significantly differ in both quality and quantity from those normally experienced on Earth. However, data on radiation exposure during space missions is often complex to access and to understand, limiting progress towards defining how radiation affects organisms against the unique background of spaceflight. To help address this challenge, we have developed the Rad-Bio-App. This web-accessible database imports radiation metadata from experiments archived in NASA’s GeneLab data repository, and then allows the user to explore these experiments both in the context of their radiation exposure and through their other metadata and results. Rad-Bio-App provides an easy-to-use, graphically-driven environment to enable both radiation biologists and non-specialist researchers to visualize, and understand the impact of ionizing radiation on various biological systems in the context of spaceflight.
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spelling pubmed-81134752021-05-12 Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures Barker, Richard Costes, Sylvain V. Miller, Jack Gebre, Samrawit G. Lombardino, Jonathan Gilroy, Simon NPJ Microgravity Comment In addition to microgravity, spaceflight simultaneously exposes biology to a suite of other stimuli. For example, in space, organisms experience ionizing radiation environments that significantly differ in both quality and quantity from those normally experienced on Earth. However, data on radiation exposure during space missions is often complex to access and to understand, limiting progress towards defining how radiation affects organisms against the unique background of spaceflight. To help address this challenge, we have developed the Rad-Bio-App. This web-accessible database imports radiation metadata from experiments archived in NASA’s GeneLab data repository, and then allows the user to explore these experiments both in the context of their radiation exposure and through their other metadata and results. Rad-Bio-App provides an easy-to-use, graphically-driven environment to enable both radiation biologists and non-specialist researchers to visualize, and understand the impact of ionizing radiation on various biological systems in the context of spaceflight. Nature Publishing Group UK 2021-05-11 /pmc/articles/PMC8113475/ /pubmed/33976230 http://dx.doi.org/10.1038/s41526-021-00143-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Barker, Richard
Costes, Sylvain V.
Miller, Jack
Gebre, Samrawit G.
Lombardino, Jonathan
Gilroy, Simon
Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures
title Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures
title_full Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures
title_fullStr Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures
title_full_unstemmed Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures
title_short Rad-Bio-App: a discovery environment for biologists to explore spaceflight-related radiation exposures
title_sort rad-bio-app: a discovery environment for biologists to explore spaceflight-related radiation exposures
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113475/
https://www.ncbi.nlm.nih.gov/pubmed/33976230
http://dx.doi.org/10.1038/s41526-021-00143-x
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