The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation

The epigenome has been shown to deteriorate with age, potentially impacting on ageing-related disease. tRNA, while arising from only ˜46 kb (<0.002% genome), is the second most abundant cellular transcript. tRNAs also control metabolic processes known to affect ageing, through core translational...

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Detalles Bibliográficos
Autores principales: Acton, Richard J., Yuan, Wei, Gao, Fei, Xia, Yudong, Bourne, Emma, Wozniak, Eva, Bell, Jordana, Lillycrop, Karen, Wang, Jun, Dennison, Elaine, Harvey, Nicholas C., Mein, Charles A., Spector, Tim D., Hysi, Pirro G., Cooper, Cyrus, Bell, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113476/
https://www.ncbi.nlm.nih.gov/pubmed/33976121
http://dx.doi.org/10.1038/s41467-021-22639-6

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